Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles

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dc.authoridOzturk, Naile / 0000-0002-7617-8433
dc.authoridOzkose, Umut Ugur / 0000-0003-4807-6322
dc.authoridGulyuz, Sevgi / 0000-0002-2576-3085
dc.authoridYILMAZ, OZGUR / 0000-0003-3892-2775
dc.authoridtasdelen, mehmet atilla / 0000-0002-7012-7029
dc.authoridKARA, ASLI / 0000-0002-0347-0222
dc.authorwosidOzturk, Naile / F-3650-2017
dc.authorwosidOzkose, Umut Ugur / AAS-3585-2021
dc.authorwosidGulyuz, Sevgi / ABI-5064-2020
dc.authorwosidYILMAZ, OZGUR / AAG-2472-2021
dc.authorwosidtasdelen, mehmet atilla / B-8338-2008
dc.contributor.authorOzturk, Naile
dc.contributor.authorKara, Asli
dc.contributor.authorGulyuz, Sevgi
dc.contributor.authorOzkose, Umut Ugur
dc.contributor.authorTasdelen, Mehmet Atilla
dc.contributor.authorBozkir, Asuman
dc.contributor.authorVural, Imran
dc.date.accessioned2021-11-01T15:05:19Z
dc.date.available2021-11-01T15:05:19Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractAims This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. Methods Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)-co-poly(ethyleneimine) (PEtOx-co-PEI) and poly(epsilon-caprolactone) (PCL) as hydrophilic and hydrophobic blocks, respectively. Doxorubicin loading, micelle size, pH-dependent drug release, and in vitro cytotoxicity on MCF-7 cells were investigated. Results The average size of drug-loaded micelles was under 100 nm and drug loading was between 10.7% and 48.3% (w/w). pH-sensitive drug release was more pronounced (84.7% and 68.9% (w/w) of drug was released at pH 5.0 and pH 7.4, respectively) for the micelles of the copolymer with the lowest PEI amount. The cell viability of doxorubicin-loaded micelles which were prepared by the copolymer with the lowest PEI amount was 28-33% at 72 h. Conclusions PEtOx-co-PEI-b-PCL micelles of this copolymer were found to be stable and effective pH-sensitive nano-sized carriers for doxorubicin delivery.
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [213M728]en_US
dc.description.sponsorshipThis study was supported by TUBITAK Grant 213M728.en_US
dc.identifier.doi10.1080/02652048.2020.1792566
dc.identifier.endpage480en_US
dc.identifier.issn0265-2048
dc.identifier.issn1464-5246
dc.identifier.issue7en_US
dc.identifier.pmid32627670
dc.identifier.scopus2-s2.0-85087898563
dc.identifier.scopusqualityQ2
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.1080/02652048.2020.1792566
dc.identifier.urihttps://hdl.handle.net/11491/7226
dc.identifier.volume37en_US
dc.identifier.wosWOS:000547724300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal Of Microencapsulation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDoxorubicinen_US
dc.subjectpoly(2-ethyl-2-oxazoline)en_US
dc.subjectpH-sensitive releaseen_US
dc.subjectpoly(ethyleneimine)en_US
dc.subjectmicellesen_US
dc.subjectblock copolymersen_US
dc.titleExploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles
dc.typeArticle

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