Immune mechanisms in human and canine demodicosis: A review

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dc.authoridTaylan-Ozkan, Aysegul / 0000-0001-8421-3625
dc.authoridMumcuoglu, Kosta / 0000-0001-8125-6099
dc.authorwosidTaylan-Ozkan, Aysegul / B-9721-2016
dc.authorwosidMumcuoglu, Kosta / AAY-2122-2020
dc.contributor.authorGazi, Umut
dc.contributor.authorTaylan-Ozkan, Aysegul
dc.contributor.authorMumcuoglu, Kosta Y.
dc.date.accessioned2021-11-01T15:02:55Z
dc.date.available2021-11-01T15:02:55Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractDemodex mites are saprophytic parasites of the mammalian skin, mostly found in or near pilosebaceous units of hairy regions. While they can be found in healthy humans and animals without causing any clinical manifestations, they were suggested to create pathogenic symptoms when they appear in high densities under favourable conditions (ie, demodicosis). Nevertheless, their role as the primary causative agent of the pathogenic conditions in humans is debated today. Canine demodicosis, which is highly prevalent in certain dog breeds, provides a valuable tool for studying the pathogenesis of human demodicosis. Canine and human demodicosis are caused by different Demodex species, and the clinical manifestations in former could be life-threatening. Nevertheless, current literature suggests similar immune responses and immune evasion mechanisms in human and canine demodicosis; cellular immunity appeared to have a central role in protection against demodicosis, and Demodex mites were shown to influence both innate and adaptive immune response to escape immune attack. The aim of this review is to summarize the relevant literature on demodicosis obtained from studies conducted on both organisms, and draw the attention to the effect of mite-associated factors (eg, microbiota) on the different clinical manifestations displayed during human and canine demodicosis.
dc.identifier.doi10.1111/pim.12673
dc.identifier.issn0141-9838
dc.identifier.issn1365-3024
dc.identifier.issue12en_US
dc.identifier.pmid31557333
dc.identifier.scopus2-s2.0-85074019597
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/pim.12673
dc.identifier.urihttps://hdl.handle.net/11491/6849
dc.identifier.volume41en_US
dc.identifier.wosWOS:000496965400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofParasite Immunology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcanineen_US
dc.subjectcell-mediated immunityen_US
dc.subjectDemodex folliculorumen_US
dc.subjecthumanen_US
dc.subjecthumoral immunityen_US
dc.subjectimmune evasionen_US
dc.titleImmune mechanisms in human and canine demodicosis: A review
dc.typeReview Article

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