Solvent effects on pKa values of some substituted sulfonamides in acetonitrile-water binary mixtures by the UV-spectroscopy method
[ X ]
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The examination of the dissociation constants of sulfonamides is essential in drug-design studies and in explaining the biopharmaceutical properties of substances. The dissociation constants of ten common human and veterinary antibiotics, namely, sulfadiazine, sulfamerazine, sulfamethoxazole, sulfathiazole, sulfamonomethoxine, sulfamethoxypyridazine, sulfadimethoxine, sulfafurazole, sulfadoxine, and sulfaquinoxaline, in water and in 15 %, 23 %, and 30 % (v/v) acetonitrile-water mixtures were determined by a UV/pH titration method and correlated with the Kamlet and Taft solvatochromic parameters, ?*, R, and ?. Kamlet and Taft's general equation was reduced to two terms by combined factor analysis and target factor analysis in these mixtures: the independent term and polarity/polarizability ?*, which is a solvatochromic parameter. Further, the quasi-lattice quasi-chemical (QLQC) theory of preferential solvation has been applied to quantify the preferential solvation by water of electrolytes in acetonitrile-water mixtures. © 2009 American Chemical Society.
Açıklama
Anahtar Kelimeler
[Belirlenecek]
Kaynak
Journal of Chemical and Engineering Data
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
54
Sayı
11
Künye
Sanli, S., Altun, Y., Sanli, N., Alsancak, G., & Beltran, J. L. (2009). Solvent Effects on p K a values of Some Substituted Sulfonamides in Acetonitrile? Water Binary Mixtures by the UV-Spectroscopy Method. Journal of Chemical & Engineering Data, 54(11), 3014-3021.
