Solvent effects on pKa values of some substituted sulfonamides in acetonitrile-water binary mixtures by the UV-spectroscopy method

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dc.contributor.authorŞanlı, Senem
dc.contributor.authorAltun, Yüksel
dc.contributor.authorŞanlı, Nurullah
dc.contributor.authorAlsancak, Güleren
dc.contributor.authorBeltran, Jose L.
dc.date.accessioned2019-05-10T09:38:56Z
dc.date.available2019-05-10T09:38:56Z
dc.date.issued2009
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe examination of the dissociation constants of sulfonamides is essential in drug-design studies and in explaining the biopharmaceutical properties of substances. The dissociation constants of ten common human and veterinary antibiotics, namely, sulfadiazine, sulfamerazine, sulfamethoxazole, sulfathiazole, sulfamonomethoxine, sulfamethoxypyridazine, sulfadimethoxine, sulfafurazole, sulfadoxine, and sulfaquinoxaline, in water and in 15 %, 23 %, and 30 % (v/v) acetonitrile-water mixtures were determined by a UV/pH titration method and correlated with the Kamlet and Taft solvatochromic parameters, ?*, R, and ?. Kamlet and Taft's general equation was reduced to two terms by combined factor analysis and target factor analysis in these mixtures: the independent term and polarity/polarizability ?*, which is a solvatochromic parameter. Further, the quasi-lattice quasi-chemical (QLQC) theory of preferential solvation has been applied to quantify the preferential solvation by water of electrolytes in acetonitrile-water mixtures. © 2009 American Chemical Society.
dc.identifier.citationSanli, S., Altun, Y., Sanli, N., Alsancak, G., & Beltran, J. L. (2009). Solvent Effects on p K a values of Some Substituted Sulfonamides in Acetonitrile? Water Binary Mixtures by the UV-Spectroscopy Method. Journal of Chemical & Engineering Data, 54(11), 3014-3021.
dc.identifier.doi10.1021/je9000813
dc.identifier.endpage3021en_US
dc.identifier.issn0021-9568
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage3014en_US
dc.identifier.urihttps://doi.org/10.1021/je9000813
dc.identifier.urihttps://hdl.handle.net/11491/553
dc.identifier.volume54en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Chemical and Engineering Data
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleSolvent effects on pKa values of some substituted sulfonamides in acetonitrile-water binary mixtures by the UV-spectroscopy method
dc.typeArticle

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