Impact of Endothelial NOS VNTR Variant on Susceptibility to Diabetic Neuropathy and Type 2 Diabetes Mellitus

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dc.authoridYigit, Serbulent / 0000-0002-1019-3964
dc.contributor.authorYigit, Serbulent
dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorUzun, Suheyla
dc.contributor.authorRustemoglu, Husniye
dc.contributor.authorDashatan, Payam Amiri
dc.contributor.authorSoylu, Huseyin
dc.contributor.authorKarakus, Nevin
dc.date.accessioned2021-11-01T15:06:04Z
dc.date.available2021-11-01T15:06:04Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractPurpose: The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN. Methods: A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was geno-typed by polymerase chain reaction (PCR) method. Results: eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p=0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively). Conclusion: The eNOS VNTR 4b/4b homozygous genotype and hence 4ballele as a genetic risk factor for T2DM and DPN, which may serve as a useful marker of increased susceptibility to the risk of these disorders.
dc.identifier.doi10.2174/1567202617999201214230147
dc.identifier.endpage705en_US
dc.identifier.issn1567-2026
dc.identifier.issn1875-5739
dc.identifier.issue5en_US
dc.identifier.pmid33319671
dc.identifier.scopus2-s2.0-85102188471
dc.identifier.scopusqualityQ3
dc.identifier.startpage700en_US
dc.identifier.urihttps://doi.org/10.2174/1567202617999201214230147
dc.identifier.urihttps://hdl.handle.net/11491/7482
dc.identifier.volume17en_US
dc.identifier.wosWOS:000621397600011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Neurovascular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndothelial NOS VNTR varianten_US
dc.subjectdiabetes mellitusen_US
dc.subjecthyperglycemiaen_US
dc.subjectdiabetic peripheral neuropathyen_US
dc.subjectgenotypeen_US
dc.subjectperipheral nerveen_US
dc.titleImpact of Endothelial NOS VNTR Variant on Susceptibility to Diabetic Neuropathy and Type 2 Diabetes Mellitus
dc.typeArticle

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