Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?

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dc.authorid0000-0002-4246-3607
dc.authorid0000-0002-0848-9731
dc.contributor.authorGörkem, Ümit
dc.contributor.authorToğrul, Cihan
dc.contributor.authorArslan, Emine
dc.contributor.authorSargın Oruç, Ayla
dc.contributor.authorBüyükkayacı Duman, Nuriye
dc.date.accessioned2019-05-13T08:58:17Z
dc.date.available2019-05-13T08:58:17Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractAim: To investigate association of kisspeptin levels in infertile women with different ovarian reserve patterns. Materials and methods: In this prospective cross-sectional study, 157 participants were recruited. The women were divided into three groups: (i) adequate ovarian reserve (AOR) (n = 57), (ii) high ovarian reserve (PCOS) (n = 60), (iii) diminished ovarian reserve (DOR) (n = 40). Weight, height, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist/hip ratio (WHR) were measured. The blood samples were analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxy progesterone (17OHP), dehydroepiandrosterone sulfate (DHEAS), antimullerian hormone (AMH), kisspeptin measurements. Results: FSH concentration was higher and AMH concentration was lower in DOR group (p <.001, p <.001, respectively). The mean LH, TT and DHEAS levels were higher in PCOS group (p =.001, p <.00 and p =.003, respectively). The 17OHP level did not differ among the groups (p =.15). Women with PCOS possessed the highest kisspeptin level (p =.01). The kisspeptin level was negatively correlated with FSH level (r = ?0.18, p =.02) and positively correlated with TT and DHEAS levels (r = 0.17, p =.02 and r = 0.23, p =.003, respectively). Conclusions: Women with PCOS had increased serum kisspeptin levels. Kisspeptin concentrations were negatively correlated with serum FSH and positively correlated with serum TT and DHEAS levels. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.citationGörkem, Ü., Toğrul, C., Arslan, E., Sargın Oruç, A., Büyükkayacı Duman, N. (2018). Is there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?. Gynecological Endocrinology, 34(2), 157-160.
dc.identifier.doi10.1080/09513590.2017.1379499
dc.identifier.endpage160en_US
dc.identifier.issn0951-3590
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2017.1379499
dc.identifier.urihttps://hdl.handle.net/11491/1108
dc.identifier.volume34en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKisspeptinen_US
dc.subjectOvarian Reserveen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.titleIs there a role for kisspeptin in pathogenesis of polycystic ovary syndrome?
dc.typeArticle

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