A validated RP-LC method for salmeterol and fluticasone in their binary mixtures and their stress degradation behavior under ICH-recommended stress conditions
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maik Nauka Publishing / Springer SBM
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Simple, accurate, precise and fully validated analytical methods for the simultaneous determination of salmeterol xinafoate and fluticasone propionate in combined dosage forms have been developed. These drugs were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the stressed samples were detected by the proposed method. Additionally, pK a values of three ionizable drugs (salmeterol xinafoate, fluticasone propionate and thioridazine) were determined using by the dependence of the retention factor on pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pK a in different acetonitrile-water mixtures, ranging between 50 and 65% (v/v) using LC-UV method. © 2014 Pleiades Publishing, Ltd.
Açıklama
Anahtar Kelimeler
Fluticasone Propionate, Liquid Chromatography, Salmeterol Xinafoate
Kaynak
Journal of Analytical Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
69
Sayı
6
Künye
Akmeşe, B., Şanlı, S., Şanlı, N., Asan, A. (2014). A validated RP-LC method for salmeterol and fluticasone in their binary mixtures and their stress degradation behavior under ICH-recommended stress conditions. Journal of Analytical Chemistry, 69(6), 563-573.
