A validated RP-LC method for salmeterol and fluticasone in their binary mixtures and their stress degradation behavior under ICH-recommended stress conditions

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dc.contributor.authorAkmeşe, Bediha
dc.contributor.authorŞanlı, Senem
dc.contributor.authorŞanlı, Nurullah
dc.contributor.authorAsan, Abdurrahman
dc.date.accessioned2019-05-13T08:59:00Z
dc.date.available2019-05-13T08:59:00Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractSimple, accurate, precise and fully validated analytical methods for the simultaneous determination of salmeterol xinafoate and fluticasone propionate in combined dosage forms have been developed. These drugs were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the stressed samples were detected by the proposed method. Additionally, pK a values of three ionizable drugs (salmeterol xinafoate, fluticasone propionate and thioridazine) were determined using by the dependence of the retention factor on pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pK a in different acetonitrile-water mixtures, ranging between 50 and 65% (v/v) using LC-UV method. © 2014 Pleiades Publishing, Ltd.
dc.identifier.citationAkmeşe, B., Şanlı, S., Şanlı, N., Asan, A. (2014). A validated RP-LC method for salmeterol and fluticasone in their binary mixtures and their stress degradation behavior under ICH-recommended stress conditions. Journal of Analytical Chemistry, 69(6), 563-573.
dc.identifier.doi10.1134/S1061934814060021
dc.identifier.endpage573en_US
dc.identifier.issn1061-9348
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.1134/S1061934814060021
dc.identifier.urihttps://hdl.handle.net/11491/1237
dc.identifier.volume69en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMaik Nauka Publishing / Springer SBM
dc.relation.ispartofJournal of Analytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFluticasone Propionateen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectSalmeterol Xinafoateen_US
dc.titleA validated RP-LC method for salmeterol and fluticasone in their binary mixtures and their stress degradation behavior under ICH-recommended stress conditions
dc.typeArticle

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