N-vinylcaprolactam-based microgels: synthesis, characterization and drug release applications
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Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Netherlands
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, N-vinylcaprolactam, metacrylic acid sodium salt and itaconic acid sodium salt-based copolymeric and terpolymeric microgels were synthesized by precipitation polymerization method with 2,2?-azobis(2-methylpropioamidine) dihydrochloride as initiator. Then these microgels were characterized by SEM technique, cloud points and colloidal properties determinations. Volume phase transitions of copolymeric and terpolymeric N-vinylcaprolactam-based microgels are determined at an interval of 32–37 °C. Rhodamine B (model drug) and Nadalol (beta-blocker drug) were used to investigate the drug loading and release behavior of microgels. It is concluded that model drug loading capacity and release amount changed with the presence and amount of itaconic acid sodium salt in the microgel structure. In addition, the maximum drug release amount of microgels was found to be 58 and 55 % for Rhodamine B and Nadolol, respectively. As a result, we can say that the microgels obtained in this study are suitable for drug delivery applications. © 2016, Springer Science+Business Media Dordrecht.
Açıklama
Anahtar Kelimeler
Drug Release, Itaconic Acid, Methacrylic Acid, Microgel, N-Vinylcaprolactam, Nadolol, Rhodamine-B
Kaynak
Research on Chemical Intermediates
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
42
Sayı
6
Künye
Özkahraman, B., Acar, I., Gök, M. K., & Güçlü, G. (2016). N-vinylcaprolactam-based microgels: synthesis, characterization and drug release applications. Research on Chemical Intermediates, 42(6), 6013-6024.
