The relation between staging fluorine-18 fluorodeoxyglucose positron emission tomog-raphy/computed tomography metabolic parameters and tumor necrosis rate in pediatric osteosarcoma patients

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dc.contributor.authorFidan, Aykut Kursat
dc.contributor.authorUcmak, Gulin
dc.contributor.authorDemirel, Bedriye Busra
dc.contributor.authorEfeturk, Hulya
dc.contributor.authorOzturk, Ipek
dc.contributor.authorDemirtas Senlik, Semra
dc.contributor.authorErgurhan Ilhan, Inci
dc.date.accessioned2021-11-01T15:05:43Z
dc.date.available2021-11-01T15:05:43Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractBackground/aim: The aim of this study was to investigate the contribution of fluorine-18 (F-18) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging in staging of pediatric osteosarcoma patients and also to evaluate the ability of metabolic parameters from the primary tumor to predict tumor necrosis rate (TNR). Material and methods: F-18 FDG-PET/CT imaging was performed in staging 37 pediatric osteosarcoma patients. The metabolic parameters SUVmax (maximum standardised uptake value), MTV (metabolic tumour volume), and TLG (total lesion glycolysis) were measured from the primary tumor. TNR level of the primary tumor was histopathologically measured after standard neoadjuvant chemotherapy treatment. The contribution of F-18 FDG-PET/CT to staging of pediatric osteosarcoma patients and the accuracy of metabolic parameters of the primary tumor to predict TNR were analized by regression analysis. Results: MTV and TLG of the primary tumor were found to efficiently predict histopathologic TNR, whereas SUVmax was not (P = 0.012, P = 0.027, P = 0.25, respectively). Also 5 of 12 patients (41.6%) who were initially defined as localised osteosarcoma were upstaged in consequence of staging F-18 FDG-PET/CT findings. Conclusion: F-18 FDG-PET/CT staging in pediatric osteosarcoma patients can effectively distinguish metastatic-localised disease. MTV and TLG values are important parameters, which can efficiently be used to predict TNR.
dc.identifier.doi10.3906/sag-2004-358
dc.identifier.endpage1122en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid33387988
dc.identifier.scopus2-s2.0-85109991916
dc.identifier.scopusqualityQ1
dc.identifier.startpage1115en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2004-358
dc.identifier.urihttps://hdl.handle.net/11491/7378
dc.identifier.volume51en_US
dc.identifier.wosWOS:000668244900026
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPediatric osteosarcomaen_US
dc.subjectpositron emission tomographyen_US
dc.subjecttumor necrosis rateen_US
dc.subjectaykutkursat@gmailen_US
dc.subjectcomen_US
dc.titleThe relation between staging fluorine-18 fluorodeoxyglucose positron emission tomog-raphy/computed tomography metabolic parameters and tumor necrosis rate in pediatric osteosarcoma patients
dc.typeArticle

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