Optical coherence tomography findings in children of patients with Alzheimer-type dementia

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dc.authorid0000-0002-9415-0039
dc.authorid0000-0002-5097-3594
dc.authorid0000-0001-5051-5713
dc.contributor.authorEliaçık, Sinan
dc.contributor.authorAykaç, Sinan
dc.contributor.authorYılmaz, Hayati
dc.date.accessioned2023-11-20T12:16:25Z
dc.date.available2023-11-20T12:16:25Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground Ocular imaging receives much attention as a source of potential biomarkers for dementia. This study aims to study structural changes in the retina and optic nerve in children of healthy and demented parents and to confrm the applicability of optic nerve tomography as a potential noninvasive marker for the early diagnosis of dementia. Methods Healthy individuals with a parent diagnosed with Alzheimer’s disease (AD) and healthy controls with healthy parents were included in the study. Included individuals had undergone Montreal Cognitive Assessment Scale and Mini-Mental Test by a single neurologist physician to confrm not having dementia. All the subjects then underwent a complete ophthalmological examination, including refractive error and keratometry readings, best-corrected visual acuity measurement with a Snellen chart (converted to LogMAR), intraocular pressure (IOP) measurement, slit-lamp biomicroscopy, dilated fundus examination, axial length measurement and optical coherence tomography (OCT) for the parapapillary retinal nerve fber layer (pRNFL), basal membrane opening—minimum rim width (BMO-MRW), and macular thickness analysis. Only the right eyes of the subjects were evaluated. OCT fndings of these two groups were compared. Results The temporosuperior sector the pRNFL thicknesses at all 3 circles (3.5, 4.1, and 4.5) were signifcantly thinner in the children of the dementia group than in healthy controls (p=0.023, 0.039, and 0.016, respectively). For the remaining sectors, the thicknesses of the pRNFL were also thinner, however, the diferences were not signifcant (p>0.05 for all). BMO-MRW at all sectors, were not also diferent signifcantly between the groups (p>0.05 for all). Parents’ dementia grade were found to be an important factor that the BMO-MRW at the temporal sector, got thinner with increasing grade (B=? 20.631, 95% CI? 42.121 to ? 0.019, and p=0.049). Conclusion We believe that OCT can be used as a noninvasive biomarker in the preclinical period, when supported by more extensive studies in people whose parents have A.
dc.identifier.citationEliaçık, S., Aykaç, S., & Yılmaz, H. (2023). Optical coherence tomography findings in children of patients with Alzheimer-type dementia. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 59(1), 98.
dc.identifier.doi10.1186/s41983-023-00701-y
dc.identifier.issn1687-8329
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s41983-023-00701-y
dc.identifier.urihttps://hdl.handle.net/11491/8686
dc.identifier.volume59en_US
dc.identifier.wosWOS:001024870800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEliaçık, Sinan
dc.language.isoen
dc.publisherSPRINGER
dc.relation.ispartofEGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOptical coherence tomographyen_US
dc.subjectParapapillary retinal nerve fber layeren_US
dc.subjectDementia patient’s childrenen_US
dc.subjectEarly diagnosis of Alzheimer’s diseaseen_US
dc.subjectBasal membrane opening-minimum rim widthen_US
dc.subjectOptic nerveen_US
dc.titleOptical coherence tomography findings in children of patients with Alzheimer-type dementia
dc.typeArticle

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