Decreased serum levels of glial markers and their relation with clinical parameters in patients with schizophrenia

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dc.contributor.authorÇetin, İhsan
dc.contributor.authorDemirel, Ömer Faruk
dc.contributor.authorSağlam, Tarık
dc.contributor.authorYıldız, Nazım
dc.contributor.authorDuran, Alaattin
dc.date.accessioned2024-01-29T07:01:32Z
dc.date.available2024-01-29T07:01:32Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: The neurodevelopmental hypothesis of schizophrenia suggests that alterations of glial fibrillary acidic protein (GFAP) and glial cell line-derived neurotrophic factor (GDNF) functions may play a role in the pathogenesis of schizophrenia. However, there is limited information about the relationship of these molecules with the clinical features of schizophrenia. In this study, it was aimed to compare patients with schizophrenia and healthy controls in terms of serum GFAP and GDNF levels and to investigate the effects of clinical parameters on serum levels of molecules in patients with schizophrenia. Method: 37 patients with schizophrenia followed in the psychosis unit and 37 age- and sex-matched healthy controls without a history of psychiatric disease were recruited in study. The patients evaluated through the Turkish version of positive and negative syndrome scale. On the other hand, sociodemographic question form was applied to both the patients and the healthy controls. Results: Serum GDNF and GFAP levels of patients with schizophrenia were significantly lower than those of healthy controls. Furthermore, serum GDNF levels were negatively correlated with general and negative syndrome scales (PANSS) in these patients. Conclusion: It has been observed that there is a relationship between PANSS and changes in the GDNF levels of schizophrenia patients. However, larger clinical studies in which these markers are also measured in cerebrospinal fluid are needed to understand the biological mechanisms underlying these associations and to understand whether glial markers could be useful as biomarkers for the diagnosis of schizophrenia
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dc.identifier.citationÇetin, İ., Demirel, Ö. F., Sağlam, T., Yıldız, N., & Duran, A. (2023). Decreased serum levels of glial markers and their relation with clinical parameters in patients with schizophrenia. TURKISH JOURNAL CLINICAL PSYCHIATRY, 26(3), 155-162.
dc.identifier.doi10.5505/kpd.2023.81557
dc.identifier.issn1302-0099
dc.identifier.issn2146-7153
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://hdl.handle.net/11491/8751
dc.identifier.wosWOS:001094376800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇetin, İhsan
dc.language.isoen
dc.publisherKLINIK PSIKIYATRI DERGISI
dc.relation.ispartofTurkish Journal of Clinical Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSchizophreniaen_US
dc.subjectNeurodegenerationen_US
dc.subjectGFAPen_US
dc.subjectGDNFen_US
dc.subjectGlial Markersen_US
dc.subjectPANSS Scoresen_US
dc.subjectŞizofrenien_US
dc.subjectNörodejenerasyonen_US
dc.subjectGFAPen_US
dc.subjectGDNFen_US
dc.subjectGlial Belirteçleren_US
dc.subjectPANSS Puanlarıen_US
dc.titleDecreased serum levels of glial markers and their relation with clinical parameters in patients with schizophrenia
dc.title.alternativeŞizofreni hastalarında azalmış serum glial belirteç düzeyleri ve bunların klinik parametrelerle ilişkisien_US
dc.typeArticle

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