A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms

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dc.contributor.authorFarag, Amir S.
dc.contributor.authorBakirhan, Nurgul K.
dc.contributor.authorSvancara, Ivan
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2021-11-01T15:02:55Z
dc.date.available2021-11-01T15:02:55Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractA novel sensor based on a modification of glassy carbon electrode (GCE) with NH2-functionalized multi walled carbon nano-tubes (NH(2)fMWCNTs) is reported and its applicability to the electrochemical sensing of Propafenone (PPF) demonstrated. The electrochemical catalytic activity was also utilized as a sensitive detection method for the investigation of the detailed redox mechanism of PFF using cyclic and and differential pulse voltammetry. The surface morphology of the sensor was investigated by SEM armed with EDX probe. Electrochemical impedance spectroscopy was employed as well to define the electron transfer capability of modified and bare electrodes. Key experimental and instrumental conditions related to electrochemical determination by cyclic, differential pulse, and square wave voltammetry, such as amount of modifier, pH, scan rate, accumulation time and potential were studied and optimized. The results have shown a significant enhancement of the peak current after modifying the electrode; the calibration curves of PPF offering good linearity from 0.1 to 10 mu M, limit of quantification (LOQ) being 0.03 mu M and limit of detection (LOD) 0.01 mu M, both when using DPV technique. The proposed sensor was successfully applied to the determination of PFF in dosage form without any special purification, separation or pre-treatment steps. The results of analyses obtained with the proposed sensor were satisfactory and fully statistically relevant. (C) 2019 Elsevier B.V. All rights reserved.
dc.description.sponsorshipFaculty of Chemical Technology, University of Pardubice; Faculty of Pharmacy, Ankara Universityen_US
dc.description.sponsorshipFinancial support from the Faculty of Chemical Technology, University of Pardubice and from Faculty of Pharmacy, Ankara University are gratefully acknowledged.en_US
dc.identifier.doi10.1016/j.jpba.2019.06.026
dc.identifier.endpage540en_US
dc.identifier.issn0731-7085
dc.identifier.issn1873-264X
dc.identifier.pmid31252310
dc.identifier.scopus2-s2.0-85067806253
dc.identifier.scopusqualityQ1
dc.identifier.startpage534en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2019.06.026
dc.identifier.urihttps://hdl.handle.net/11491/6855
dc.identifier.volume174en_US
dc.identifier.wosWOS:000479328000062
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal Of Pharmaceutical And Biomedical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectElectrochemistryen_US
dc.subjectGlassy carbon electrodeen_US
dc.subjectNanotubesen_US
dc.subjectPropafenoneen_US
dc.subjectDrug analysisen_US
dc.titleA new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms
dc.typeArticle

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