A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation

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dc.contributor.authorAsfuroglu, Mahmut
dc.contributor.authorAsfuroglu, Yonca
dc.date.accessioned2021-11-01T15:01:54Z
dc.date.available2021-11-01T15:01:54Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractA 38-year-old man with a diagnosis of BRAF-mutated metastatic melanoma was referred to our clinic. He had been under treatment with 60-mg oral cobimetinib daily for 21 days/7 day off in combination with 960 mg vemurafenib twice daily. The patient had symptoms of blurred vision and photophobia in his right eye. A slit-lamp examination revealed bilateral central corneal stromal opacity and epithelial microcystic edema Involvement was more severe in the right eye compared with the left eye. Fourteen days after the first visit, the patient's symptoms and slit-lamp findings were largely resolved. We suggest that endothelium pump failure was involved in this acute corneal decompensation case similar to the mechanism in retinal pigment epithelium.
dc.identifier.doi10.4103/ijo.IJO_2025_18
dc.identifier.endpage+en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.issue12en_US
dc.identifier.pmid31755464
dc.identifier.scopus2-s2.0-85075462223
dc.identifier.scopusqualityQ2
dc.identifier.startpage2073en_US
dc.identifier.urihttps://doi.org/10.4103/ijo.IJO_2025_18
dc.identifier.urihttps://hdl.handle.net/11491/6751
dc.identifier.volume67en_US
dc.identifier.wosWOS:000511463500045
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal Of Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCorneal decompensationen_US
dc.subjectcobimetiniben_US
dc.subjectMEK inhibitoren_US
dc.titleA novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation
dc.typeArticle

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