Aloe vera-based antibacterial porous sponges for wound dressing applications

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dc.authoridBal Öztürk, Ayça / 0000-0002-6502-528X
dc.authorwosidBal Öztürk, Ayça / M-4472-2018
dc.authorwosidBoran, Filiz / AAF-5285-2021
dc.contributor.authorTamahkar, Emel
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorYarimcan, Filiz
dc.contributor.authorBoran, Filiz
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-11-01T15:06:00Z
dc.date.available2021-11-01T15:06:00Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.description.abstractThe antibacterial sponges with high macroporosity, high interconnectivity and high biocompatibility is a significant concern for wound healing applications. In this work, novel Aloe vera (AV) based sponges were developed via subsequent lyophilization with further chemical crosslinking throughout the double network sponges. Single network was composed of gelatin-sodium alginate (G-SA) while the double network using gelatin-sodium alginate- sodium hyaluronate (G-SA-HA) was produced with the addition of hyaluronic acid solution into the gelatin-sodium alginate matrix. Lastly, Aloe vera as the bioactive agent was fabricated throughout the gelatin-sodium alginate-sodium hyaluronate matrix. The AV-based sponges demonstrated large pores with high interconnectivity. The swelling degree of the AV-based sponges were higher than that of G-SA and G-SA-HA sponges. The release of AV from the sponges reached an equilibrium value after 24 h showing a more controlled release at pH 5.5 than at pH 7.4. AV-based sponges showed antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pneumoniae and Bacillus cereus and displayed any cytotoxicity against Mesenchymal stem cells.
dc.description.sponsorshipScientific Projects Coordination Unit of Hitit UniversityHitit University [MUH19001.18.001]; Hitit University Scientific and Tecnical Application and Research Centeren_US
dc.description.sponsorshipThe financial support from the Scientific Projects Coordination Unit of Hitit University under the project number MUH19001.18.001 is gratefully acknowledged. The authors are also greateful to the support of Hitit University Scientific and Tecnical Application and Research Center.en_US
dc.identifier.citationTamahkar, E., Özkahraman, B., Özbaş, Z., Izbudak, B., Yarimcan, F., Boran, F., & Öztürk, A. B. (2021). Aloe vera-based antibacterial porous sponges for wound dressing applications. Journal of Porous Materials, 28(3), 741-750.
dc.identifier.doi10.1007/s10934-020-01029-1
dc.identifier.endpage750en_US
dc.identifier.issn1380-2224
dc.identifier.issn1573-4854
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85100181974
dc.identifier.scopusqualityQ2
dc.identifier.startpage741en_US
dc.identifier.urihttps://doi.org/10.1007/s10934-020-01029-1
dc.identifier.urihttps://hdl.handle.net/11491/7465
dc.identifier.volume28en_US
dc.identifier.wosWOS:000608662700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTamahkar, Emel
dc.institutionauthorÖzkahraman, Bengi
dc.institutionauthorBoran, Filiz
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal Of Porous Materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectWound Dressingsen_US
dc.subjectHydrogelen_US
dc.subjectAntibacterial Spongeen_US
dc.subjectAloe Veraen_US
dc.titleAloe vera-based antibacterial porous sponges for wound dressing applications
dc.typeArticle

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