The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps

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dc.contributor.authorEkinci, Adnan
dc.contributor.authorKayadibi, Hüseyin
dc.contributor.authorDemir, Emre
dc.contributor.authorÖzcan, Müge
dc.date.accessioned2021-11-01T15:05:37Z
dc.date.available2021-11-01T15:05:37Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: To compare prolidase enzyme activity (PEA) in serum and polyp specimens of patients with nasal polyps obtained before and after the oral steroid therapy. Materials and methods: Thirty three patients with nasal polyps (39 +/- 13 years) received 1 mg/kg of oral steroids. Serum samples were collected from each patient, but nasal polyp specimens could be obtained only from 23 patients (38 +/- 13 years) before and after the oral steroid therapy. PEA was measured by ELISA method. Results: Serum PEA values were 210 (176-242) U/L and 184 (147-217) U/L before and after the oral steroid therapy, respectively (p = 0.015). Polyp tissue PEA was 1337 (738-2130) U/g and 871 (590-1663) U/g before and after the oral steroid therapy, respectively (p = 0.429). Conclusion: In patients with nasal polyps, significantly lower serum PEA after the oral steroid therapy may be a consequence of the role of prolidase enzyme in inflammatory processes which are important for the development of nasal polyps. More comprehensive studies with larger sample sizes are needed to elucidate the role of PEA in the pathogenesis of nasal polyps.
dc.description.sponsorshipHitit UniversityHitit University [TIP19002.16.008]en_US
dc.description.sponsorshipThis study was funded by Hitit University. Project number is TIP19002.16.008.en_US
dc.identifier.citationEkinci, A., Kayadibi, H., Demir, E., & Ozcan, M. (2021). The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps. Turkish Journal of Biochemistry, 46(4), 473-477.
dc.identifier.doi10.1515/tjb-2019-0204
dc.identifier.endpage477en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85115436047
dc.identifier.scopusqualityQ3
dc.identifier.startpage473en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2019-0204
dc.identifier.urihttps://hdl.handle.net/11491/7344
dc.identifier.volume46en_US
dc.identifier.wosWOS:000693607700017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEkinci, Adnan
dc.institutionauthorDemir, Emre
dc.institutionauthorKayadibi, Hüseyin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNasal Polypen_US
dc.subjectProlidaseen_US
dc.subjectSteroid Therapyen_US
dc.subjectInflammationen_US
dc.subjectFibrosisen_US
dc.titleThe effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps
dc.typeArticle

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