Can Bone-Specific Alkaline Phosphatase and Osteocalcine Levels Be Used to Determine the Age in Children?

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dc.contributor.authorTopal, Ismail
dc.contributor.authorGumus, Burak
dc.date.accessioned2021-11-01T15:03:13Z
dc.date.available2021-11-01T15:03:13Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractBackground Demand for age determination by medical methods from legal authorities is of critical importance, especially for people in pubertal age. We planned this study to evaluate the potential utility of biochemical methods in these applications. We aim to investigate whether alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP), and osteocalcine can be used in the determination of age. Materials and Methods A total of 146 children (85 girls, 61 boys) between the ages of 9 and 16 years participated in the study. Considering legally defined age limits, we did the age grouping at the following intervals: we formed 3 different subgroups, (1) 9 to 11 years age group, (2) 12 to 14 years age group, and (3) 15 to 16 years age group. As the physiological growth and development processes changed according to sex, all calculations were done separately for girls and boys. Results Our data indicate that ALP and BALP values for girls can be used for age determination with acceptable sensitivity and specificity. However, we could not observe such precise distinction for boys. Although BALP is claimed to be superior to ALP, we have not found any evidence to confirm this in our study. Conclusions This study provides sex- and age-dependent cutoff values for ALP and BALP for the girl, which may be useful for age determination.
dc.identifier.doi10.1097/PAF.0000000000000555
dc.identifier.endpage187en_US
dc.identifier.issn0195-7910
dc.identifier.issn1533-404X
dc.identifier.issue3en_US
dc.identifier.pmid32796205
dc.identifier.scopus2-s2.0-85089547521
dc.identifier.scopusqualityQ3
dc.identifier.startpage182en_US
dc.identifier.urihttps://doi.org/10.1097/PAF.0000000000000555
dc.identifier.urihttps://hdl.handle.net/11491/7028
dc.identifier.volume41en_US
dc.identifier.wosWOS:000565271400009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAmerican Journal Of Forensic Medicine And Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectalkaline phosphataseen_US
dc.subjectbone-specific alkaline phosphataseen_US
dc.subjectosteocalcineen_US
dc.subjectage determinationen_US
dc.titleCan Bone-Specific Alkaline Phosphatase and Osteocalcine Levels Be Used to Determine the Age in Children?
dc.typeArticle

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