The Effect of Large Simple Renal Cysts on Serum Renalase/Epinephrine Ratio and Angiotensinogen Levels

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dc.contributor.authorEser, Barış
dc.contributor.authorÇalışkan, Selahattin
dc.contributor.authorDoğan, İbrahim
dc.contributor.authorYayar, Özlem
dc.contributor.authorSungur, Mustafa
dc.contributor.authorKayadibi, Hüseyin
dc.date.accessioned2021-11-01T18:14:59Z
dc.date.available2021-11-01T18:14:59Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractObjective: Large solitary renal cysts (SRC) may result in renal ischemia. Renalase, a protective enzyme against ischemic renal injury, has an effective role in controlling blood pressure (BP). Therefore, we aimed to investigate the relationships among pre- and postoperative serum angiotensinogen, epinephrine, renalase/epinephrine ratio, and BP in patients who underwent laparoscopic cyst decortication. Materials and Methods: We included 20 patients with large SRC and 16 healthy individuals in this prospective study. Cysts were diagnosed by ultrasonography and characterized using computed tomography. Blood and urine samples were collected during pre- and postoperative periods. In addition, 12-hour ambulatory BP values were recorded. Serum angiotensinogen, renalase, and epinephrine levels were measured by the enzyme-linked immunosorbent assay method. Results: There was no statistically significant difference in angiotensinogen and renalase levels between patient and control groups (p=0.205, p=0.163, respectively), but preoperative renalase/epinephrine ratio was significantly higher in patients (p=0.006) than in the control group. In addition, renalase/epinephrine ratio was significantly lower in the postoperative period (p=0.018). Univariate and multivariate logistic regression analyses demonstrated that a higher renalase/epinephrine ratio was associated with the presence of SRC (p=0.028, p=0.016, respectively). Conclusion: A high renalase/epinephrine ratio may be associated with the presence of large SRC. We think that renalase may be a biomarker in the management of SRC and decision making in surgical procedures. Association of renalase with large SRC should be explored in future studies.
dc.identifier.doi10.5152/turkjnephrol.2020.3998
dc.identifier.endpage160en_US
dc.identifier.issn1300-7718
dc.identifier.issn2667-4440
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85087987241
dc.identifier.scopusqualityQ4
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org10.5152/turkjnephrol.2020.3998
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRJek1qSXdNQT09
dc.identifier.urihttps://hdl.handle.net/11491/7626
dc.identifier.volume29en_US
dc.identifier.wosWOS:000533604700008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofTurkish journal of nephrology (Online)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject[No Keywords]en_US
dc.titleThe Effect of Large Simple Renal Cysts on Serum Renalase/Epinephrine Ratio and Angiotensinogen Levels
dc.typeArticle

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