The efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population

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dc.contributor.authorAltunören, Orçun
dc.contributor.authorGüngör, Özkan
dc.contributor.authorEren, Necmi
dc.contributor.authorTanrısev, Mehmet
dc.contributor.authorHür, Ender
dc.contributor.authorTürkmen, Kültigin
dc.contributor.authorCoşkun Yavuz, Yasemin
dc.contributor.authorDoğan, İbrahim
dc.date.accessioned2019-05-13T09:03:04Z
dc.date.available2019-05-13T09:03:04Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. In this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients. MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. The patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). The patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months. RESULTS: The levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p<0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month). CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population.
dc.identifier.citationAltunören, O., Güngör, O., Eren, N., Tanrisev, M., Hür, E., Türkmen, K., ... & Koçyigit, I. (2016). The efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population.
dc.identifier.doi10.5262/tndt.2016.1002.12
dc.identifier.endpage198en_US
dc.identifier.issn1300-7718
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.5262/tndt.2016.1002.12
dc.identifier.urihttps://hdl.handle.net/11491/1397
dc.identifier.volume25en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkish Society of Nephrology
dc.relation.ispartofTurkish Nephrology, Dialysis and Transplantation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic Renal Failureen_US
dc.subjectCinacalceten_US
dc.subjectHemodialysisen_US
dc.subjectParathormoneen_US
dc.subjectSecondary Hyperparathyroidismen_US
dc.titleThe efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population
dc.title.alternativeTürk hemodiyaliz hasta popülasyonunda hiperparatiroidizm tedavisinde Sinakalset’in etkinliğien_US
dc.typeArticle

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