Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Little is known about the protective effects of carvacrol on the symptoms of streptozotocin induced diabetes in rats. Hence, this present study was designed to evaluate the protective effect of the strong antioxidant, carvacrol, on the symptoms of streptozotocin induced diabetes in rats. Carvacrol at the doses of 25 and 50 mg/kg body weight were orally administered to diabetic rats for a period of 7 days after the onset of diabetes. Food-water intake and body weight changes were daily recorded. Biochemical parameters such as serum glucose, insulin, total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase were measured. Although treatment of diabetic rats with oral administration of carvacrol resulted in a slight reduction in serum glucose level and significant reduction in serum total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase in comparison with diabetic control rats, there were no significant differences in serum insulin levels, food-water intake values and body weight changes. Despite the inadequacy of carvacrol on diabetes treatments, it was determined to have at least a partially protective role on liver enzymes. © 2013 The Author(s).
Açıklama
Anahtar Kelimeler
Carvacrol, Diabetes, Liver, Rat, Streptozotocin
Kaynak
Cytotechnology
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
66
Sayı
2
Künye
Bayramoğlu, G., Şentürk, H., Bayramoğlu, A., Uyanoğlu, M., Çolak, S., Özmen, A., Kolankaya, D. (2014). Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats. Cytotechnology, 66(2), 251-257.
