Eosinophil percentage as a new prognostic marker in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

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dc.authorwosidÖsken, Altuğ / AAW-7198-2021
dc.contributor.authorGüner, Ahmet
dc.contributor.authorZehir, Regayip
dc.contributor.authorKalçık, Macit
dc.contributor.authorUslu, Abdulkadir
dc.contributor.authorÖsken, Altuğ
dc.contributor.authorKalkan, Ali Kemal
dc.contributor.authorGültekin Güner, Ezgi
dc.date.accessioned2021-11-01T15:02:56Z
dc.date.available2021-11-01T15:02:56Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: In addition to proinflammatory properties, eosinophils can stimulate platelet activation and enhance prothrombotic pathways. In this study, we aimed to investigate the association between the eosinophil percentage (EOS%) and major adverse cardiac events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI). Methods: This study enrolled a total of 1,909 patients who were diagnosed with STEMI. Ventricular arrhythmia, reinfarction, the need for cardiopulmonary resuscitation, target vessel revascularization, congestive heart failure, and cardiovascular mortality during index hospitalization were defined as MACE. Results: Three hundred and eighty patients (19.7%) reached the combined endpoint with MACE. The rates of inhospital mortality and MACE were significantly higher in low EOS% group as compared to high EOS% group (4% vs. 1.1%, p < 0.01 and 32.8% vs. 11.3%, p < 0.01, respectively). On multivariate logistic regression analyses, EOS% (OR = 0.44, p < 0.01) was found to be one of the independent predictors of MACE. The EOS% lower than 0.60 on admission predicted inhospital MACE with a sensitivity of 68% and a specificity of 72% (AUC: 0.684, p < 0.01). Conclusions: Low EOS% on admission may be associated with high inhospital MACE in STEMI patients. EOS% may be used as a novel biomarker for risk stratification of these patients.
dc.identifier.citationGüner, A., Zehİr, R., KalçIk, M., Uslu, A., Ösken, A., Kalkan, A. K., & Güner, E. G. (2020). Eosinophil percentage as a new prognostic marker in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Interventional Medicine and Applied Science, 11(3), 146-153.
dc.identifier.doi10.1556/1646.11.2019.17
dc.identifier.endpage153en_US
dc.identifier.issn2061-1617
dc.identifier.issn2061-5094
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85094136401
dc.identifier.scopusqualityN/A
dc.identifier.startpage146en_US
dc.identifier.urihttps://doi.org/10.1556/1646.11.2019.17
dc.identifier.urihttps://hdl.handle.net/11491/6869
dc.identifier.volume11en_US
dc.identifier.wosWOS:000576384300004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKalçık, Macit
dc.language.isoen
dc.publisherAkademiai Kiado Zrt
dc.relation.ispartofInterventional Medicine And Applied Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectComplete Blood Countsen_US
dc.subjectEosinophil Percentageen_US
dc.subjectInflammationen_US
dc.subjectMajor Adverse Cardiac Eventsen_US
dc.subjectMyocardial Infarctionen_US
dc.titleEosinophil percentage as a new prognostic marker in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
dc.typeArticle

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