Therapeutic Effects of tDCS on Calcium and Glutamate Excitotoxicity in a Cerebral Ischemia-Reperfusion Rat Model

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dc.contributor.authorAkçay, G
dc.contributor.authorDemirdöğen, F
dc.contributor.authorKotan, D
dc.contributor.authorGül, T
dc.contributor.authorYılmaz, A
dc.contributor.authorErgül, YM
dc.contributor.authorÇelik, C
dc.date.accessioned2026-03-31T13:21:20Z
dc.date.available2026-03-31T13:21:20Z
dc.date.issued2025
dc.description.abstractAIM: To investigate the therapeutic effects of transcranial direct current stimulation (tDCS) on calcium and glutamate excitotoxicity caused by ischemia-reperfusion (IR). MATERIAL and METHODS: The IR model was generated by transient middle cerebral artery occlusion. tDCS treatment was applied at 1 mA for 30 min daily at the 2nd, 24th, and 48th h of IR. The motor and cognitive functions and the concentrations of Ca2+, glutamate, and N-methyl-D-aspartate receptor (NMDAR) in the hippocampus tissues were evaluated. RESULTS: Results showed a reduction in motor and cognitive functions in the IR group compared with that in the sham group, whereas these functions increased in the IR+tDCS group compared with those in the IR group. Ca2+, glutamate, and NMDAR concentrations were higher in the IR group than in the sham group but lower in the IR+tDCS group than in the IR group. CONCLUSION: These results suggest that tDCS treatment improves motor and cognitive dysfunctions after IR and exerts therapeutic effects on learning and memory through the regulation of Ca2+ and glutamate excitotoxicity.
dc.identifier.doi10.5137/1019-5149.JTN.46166-23.6
dc.identifier.issn1019-5149
dc.identifier.issue5
dc.identifier.pmid40905808
dc.identifier.urihttp://dx.doi.org/10.5137/1019-5149.JTN.46166-23.6
dc.identifier.urihttps://hdl.handle.net/11491/9695
dc.identifier.volume35
dc.identifier.wosWOS:001588170700011
dc.language.isoen
dc.publisherTURKISH NEUROSURGICAL SOC
dc.relation.ispartofTURK NEUROSURG
dc.subjectExcitotoxicity
dc.subjectGlutamate
dc.subjectIschemia-reperfusion
dc.subjecttDCS
dc.titleTherapeutic Effects of tDCS on Calcium and Glutamate Excitotoxicity in a Cerebral Ischemia-Reperfusion Rat Model
dc.typeArticle

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