Urinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems

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dc.authoridTURGUT, DIDEM / 0000-0001-7474-5927
dc.authorwosidTURGUT, DIDEM / AAI-9418-2021
dc.contributor.authorTurgut, Didem
dc.contributor.authorPiskinpasa, Serhan Vahit
dc.contributor.authorYenigun, Ezgi Coskun
dc.contributor.authorAydemir, Nihal
dc.contributor.authorDede, Fatih
dc.date.accessioned2021-11-01T15:05:14Z
dc.date.available2021-11-01T15:05:14Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractBackground/aim: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used in the differential diagnosis of underlying AKI etiologies. Materials and methods: In this prospective cross-sectional study, we examined 82 subjects in four groups: patients that had (1) postrenal AKI; (2) AKI other than postrenal etiologies; (3) stable chronic kidney disease; and (4) healthy subjects. A renal function assessment was carried out by measuring serum creatininc (sCr) and uNGAL at the time of diagnosis [0th min (T0)]. We followed the study group for three months. Results: At the time of diagnosis, sCr (T0) was highest in the postrenal AKI and AKI groups in contrast to stable chronic kidney disease patients and healthy subjects (P < 0.001), as expected. T0 median uNGAL was highest in the postrenal group (P < 0.001). Area under curve (AUC) of uNGAL to estimate postrenal AKI presence was 0.957 (95% CI, 0.897-1.000; P < 0.001). The cut-off point of uNGAL was 42.625 ng/mL for this estimation. Conclusion: Patients with AKI must be classified according to the underlying etiologies as soon as possible. uNGAL may be useful to estimate the etiologies, and whether the problem is acute or chronic in the course. In postrenal kidney problems, to plan the urgency of the urologic procedures, it is crucial.
dc.identifier.doi10.3906/sag-2002-130
dc.identifier.endpage1572en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid32927927
dc.identifier.scopus2-s2.0-85093663120
dc.identifier.scopusqualityQ1
dc.identifier.startpage1566en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2002-130
dc.identifier.urihttps://hdl.handle.net/11491/7185
dc.identifier.volume50en_US
dc.identifier.wosWOS:000582190800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute kidney injuryen_US
dc.subjecturinary neutrophil gelatinase-associated lipocalin (uNGAL)en_US
dc.subjectpostrenalen_US
dc.subjectcut-off valueen_US
dc.titleUrinay neutrophil gelatinase-associated lipocalin as a biomarker in different renal problems
dc.typeArticle

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