Determination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms
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Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Friedr. Vieweg und Sohn Verlags GmbH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The pK a values of cefdinir and cefixime, which are used in the treatment of bacterial infections, have been determined precisely in water and methanol-water binary mixtures (20% v/v) using spectrophotometric titration and LC, respectively. A simple, fast and precise isocratic high-performance liquid chromatographic (LC) procedure has been developed for the determination of cefdinir and cefixime in drug formulations. This method was validated successfully for specificity, precision, linearity, range, accuracy, limit of detection, and limit of quantitation as per the ICH guidelines. The proposed method can be used for routine analysis of studied cephalosporin compounds and as an alternative tool for drug quality control laboratories. © 2011 Springer-Verlag.
Açıklama
Anahtar Kelimeler
Cefdinir, Cefixime, Column Liquid Chromatography, Dissociation Constants
Kaynak
Chromatographia
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
73
Sayı
11.Dec
Künye
Sanli, N., Sanli, S., Sızır, U., Gumustas, M., Ozkan, S. A. (2011). Determination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms. Chromatographia, 73(11-12), 1171-1176.
