Determination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms

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dc.authorid0000-0003-2793-7154
dc.authorid0000-0001-7494-3077
dc.contributor.authorŞanlı, Nurullah
dc.contributor.authorŞanlı, Senem
dc.contributor.authorSızır, Ümit
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:38:50Z
dc.date.available2019-05-10T09:38:50Z
dc.date.issued2011
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe pK a values of cefdinir and cefixime, which are used in the treatment of bacterial infections, have been determined precisely in water and methanol-water binary mixtures (20% v/v) using spectrophotometric titration and LC, respectively. A simple, fast and precise isocratic high-performance liquid chromatographic (LC) procedure has been developed for the determination of cefdinir and cefixime in drug formulations. This method was validated successfully for specificity, precision, linearity, range, accuracy, limit of detection, and limit of quantitation as per the ICH guidelines. The proposed method can be used for routine analysis of studied cephalosporin compounds and as an alternative tool for drug quality control laboratories. © 2011 Springer-Verlag.
dc.identifier.citationSanli, N., Sanli, S., Sızır, U., Gumustas, M., Ozkan, S. A. (2011). Determination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms. Chromatographia, 73(11-12), 1171-1176.
dc.identifier.doi10.1007/s10337-011-2013-7
dc.identifier.endpage1176en_US
dc.identifier.issn0009-5893
dc.identifier.issue11.Decen_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1171en_US
dc.identifier.urihttps://doi.org/10.1007/s10337-011-2013-7
dc.identifier.urihttps://hdl.handle.net/11491/501
dc.identifier.volume73en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherFriedr. Vieweg und Sohn Verlags GmbH
dc.relation.ispartofChromatographia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCefdiniren_US
dc.subjectCefiximeen_US
dc.subjectColumn Liquid Chromatographyen_US
dc.subjectDissociation Constantsen_US
dc.titleDetermination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms
dc.typeArticle

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