The MIF rs755622 Variant may Increase Susceptibility of Breast Cancer but not Gastrointestinal Cancer in a Turkish Population

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dc.contributor.authorPehlivan, Sacide
dc.contributor.authorIşıksaçan, Nilgün
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorGünaldı, Meral
dc.contributor.authorOyacı, Yasemin
dc.contributor.authorNursal, Ayşe Feyda
dc.date.accessioned2021-11-01T18:15:01Z
dc.date.available2021-11-01T18:15:01Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractOBJECTIVE An increasing number of epidemiological and molecular evidence proposes that inflammation is a significant factor in the etiology of cancers. Macrophage Migration Inhibitory Factor (MIF) encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It has been reported that MIF is linked with a higher risk of several cancer types. In the present study, we investigated the association of MIF rs755622 variant with the risk of breast cancer (BC) and gastrointestinal cancer in a Turkish cohort. METHODS The present study included a total of 153 subjects, which consisted of 33 BC patients, 53 gastrointestinal cancer patients and 67 healthy controls. Genomic DNA extracted from peripheral venous blood. The rs755622 variant of the MIF gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The results were statistically analyzed by calculating the odds ratios (OR) and 95% confidence intervals (CI) using the ?2 test. RESULTS There was a statistical difference between the BC patients and controls for the MIF rs755622 variant. MIF rs755622 GG genotype and G allele were increased in BC patients compared to controls (p=0.016, p=0.017, respectively). No significant difference was observed between gastrointestinal cancer patients and controls for the MIF rs755622 variant (p>0.05). CONCLUSION Our results showed that the MIF rs755622 variant might play a potential role in BC physiopathology.
dc.identifier.doi10.5505/tjo.2020.2186
dc.identifier.endpage288en_US
dc.identifier.issn1300-7467
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85091336939
dc.identifier.scopusqualityQ4
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org10.5505/tjo.2020.2186
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpnd05ERTJOZz09
dc.identifier.urihttps://hdl.handle.net/11491/7641
dc.identifier.volume35en_US
dc.identifier.wosWOS:000565170700006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofTürk Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject[No Keywords]en_US
dc.titleThe MIF rs755622 Variant may Increase Susceptibility of Breast Cancer but not Gastrointestinal Cancer in a Turkish Population
dc.typeArticle

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