Epicardial adipose tissue is associated with increased systolic pulmonary artery pressure in patients with chronic obstructive pulmonary disease

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dc.authoridKALAYCIOGLU, EZGI / 0000-0003-2122-1817
dc.authoridCetin, Mustafa / 0000-0001-6342-436X
dc.authorwosidKALAYCIOGLU, EZGI / ABG-6777-2020
dc.authorwosidCetin, Mustafa / A-2919-2016
dc.contributor.authorKalaycioglu, Ezgi
dc.contributor.authorCetin, Mustafa
dc.contributor.authorCinier, Goksel
dc.contributor.authorOzyildiz, Ali Gokhan
dc.contributor.authorDurmus, Ismet
dc.contributor.authorKiris, Tuncay
dc.contributor.authorGokdeniz, Tayyar
dc.date.accessioned2021-11-01T15:06:13Z
dc.date.available2021-11-01T15:06:13Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractObjectives Pulmonary hypertension (PHT) is one of the essential predictors of mortality in chronic obstructive pulmonary disease (COPD). It is thought that PHT is due to vasoconstriction secondary to hypoxia caused by airway obstruction in COPD patients; however, loss of capillary bed with emphysema, inflammation, and endothelial dysfunction may also play a role in the development of PHT. Epicardial adipose tissue (EAT) has a role as a metabolically active endocrine organ and secretes various proinflammatory cytokines. We hypothesized that EAT thickness in COPD patients might be associated with the systolic pulmonary arterial pressure (PAPs) level, and we aimed to test it. Methods The present study included 129 consecutive patients with the diagnosis of COPD. All patients underwent transthoracic echocardiographic evaluation. The relationship between PAPs and EAT thickness was evaluated. Results Positive correlations with PAPs were reported with age, EAT, white blood cell (WBC) and GOLD grade score (range 0.197-0.275, P values 0.026 to 0.002), negative correlations with body-mass index (BMI), hyperlipidemia, FEV1 (% predicted) and pO2 (range -0.216 to -0.340, P values .014 to <.001). In stepwise linear regression analysis, BMI (P = .003), EAT (P = .002), WBC (P = .001), and FEV1 (% predicted) (P = .010), were independently associated with PAPs. Conclusion EAT thickness in COPD patients with preserved left ventricular systolic function is associated with increased PAPs, and this association is independent of the parameters indicating the severity of COPD.
dc.identifier.doi10.1111/crj.13316
dc.identifier.endpage412en_US
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue4en_US
dc.identifier.pmid33269556
dc.identifier.scopus2-s2.0-85097778954
dc.identifier.scopusqualityQ3
dc.identifier.startpage406en_US
dc.identifier.urihttps://doi.org/10.1111/crj.13316
dc.identifier.urihttps://hdl.handle.net/11491/7519
dc.identifier.volume15en_US
dc.identifier.wosWOS:000599727600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectepicardial adipose tissueen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectsystolic pulmonary arterial pressureen_US
dc.titleEpicardial adipose tissue is associated with increased systolic pulmonary artery pressure in patients with chronic obstructive pulmonary disease
dc.typeArticle

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