Therapeutic Effects of Newly Synthesized Boron Compounds (BGM and BGD) on Hepatocellular Carcinoma

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dc.authoridBülter Bolat, Melda / 0000-0002-6923-322X
dc.authorwosidBülter Bolat, Melda / AAM-1380-2021
dc.authorwosidBerikten, Derya / AAP-4792-2021
dc.contributor.authorKoldemir Gündüz, Meliha
dc.contributor.authorBülter Bolat, Melda
dc.contributor.authorKaymak, Güllü
dc.contributor.authorBerikten, Derya
dc.contributor.authorKöse, Dursun Ali
dc.date.accessioned2021-11-01T15:05:39Z
dc.date.available2021-11-01T15:05:39Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.departmentHitit Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Mülkiyet Koruma ve Güvenlik Bölümü
dc.description.abstractBoron has an important potential for facilitating biological activity and for use in pharmaceutical drug design. Boron glycine monoester (BGM) and boron glycine diester (BGD) compounds containing boron atoms were synthesized and investigated their cytotoxic, oxidative stress, and antimicrobial activities on the HepG2 cancer cell line. The cytotoxic activity of newly synthesized boron compounds on hepatocellular carcinoma was determined by the MTT method for 48 h. Antioxidant (CAT, GSH), lipid peroxidation (MDA), and enzyme activity (ACP, ALP) analyses were determined by spectrophotometric methods in HepG2 cells. Antimicrobial activity was determined by the disk diffusion method. After 48 h of BGM and BGD application to HepG2 cells, we found the IC50 values as 9.9 mM and 24 mM, respectively. While CAT and ACP enzyme activities decreased in all groups compared to the control, ALP enzyme activity did not change in the BGM group but increased in the BGD group. It was determined that the GSH level did not change in all groups, while the MDA level increased. It has been stated that these IC50 doses of BGM and BGD have antibacterial effects on Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922. Newly synthesized boron compounds, particularly BGM, with their cytotoxic, oxidative stress, and antimicrobial effects, could provide a new therapeutic approach for the treatment of hepatocellular carcinoma.
dc.description.sponsorshipNational Boron Institute (BOREN) [2020-30-06-30-002]en_US
dc.description.sponsorshipThe authors received support from the National Boron Institute (BOREN) for the research project (2020-30-06-30-002).en_US
dc.identifier.citationGündüz, M. K., Bolat, M., Kaymak, G., Berikten, D., & Köse, D. A. (2022). Therapeutic effects of newly synthesized boron compounds (BGM and BGD) on hepatocellular carcinoma. Biological Trace Element Research, 200(1), 134-146.
dc.identifier.doi10.1007/s12011-021-02647-9
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.pmid33634364
dc.identifier.scopus2-s2.0-85101748088
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02647-9
dc.identifier.urihttps://hdl.handle.net/11491/7359
dc.identifier.wosWOS:000621711800002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBülter Bolat, Melda
dc.institutionauthorKöse, Dursun Ali
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBoron glycine monoesteren_US
dc.subjectBoron glycine diesteren_US
dc.subjectHepG2en_US
dc.subjectOxidative stressen_US
dc.subjectAntimicrobialen_US
dc.titleTherapeutic Effects of Newly Synthesized Boron Compounds (BGM and BGD) on Hepatocellular Carcinoma
dc.typeArticle

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