Nickel ferrite nanoparticles for simultaneous use in magnetic resonance imaging and magnetic fluid hyperthermia

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dc.authoridCoşkun, Mustafa / 0000-0001-9479-4363
dc.authoridPineider, Francesco / 0000-0003-4066-4031
dc.authoridBerti, Debora / 0000-0001-8967-560X
dc.authoridUmut, Evrim / 0000-0003-0344-1365
dc.authoridGüngüneş, Hakan / 0000-0002-5803-3193
dc.authorwosidUmut, Evrim / Q-4493-2019
dc.authorwosidCoşkun, Mustafa / AAP-1320-2020
dc.authorwosidPineider, Francesco / K-9174-2013
dc.authorwosidBerti, Debora / G-6525-2011
dc.contributor.authorUmut, Evrim
dc.contributor.authorCoşkun, Mustafa
dc.contributor.authorPineider, Francesco
dc.contributor.authorBerti, Debora
dc.contributor.authorGüngüneş, Hakan
dc.date.accessioned2021-11-01T15:02:59Z
dc.date.available2021-11-01T15:02:59Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü
dc.description.abstractWe demonstrate magnetic resonance imaging (MRI) contrast enhancement and ac-field induced heating abilities of tetramethylammoniumhydroxide (TMAH) coated nickel ferrite (NiFe2O4) nanoparticles and discuss the underlying physical mechanisms. The structural characterization revealed that the NiFe2O4 particles synthesized with a modified co-precipitation method have a very narrow size distribution with a 4.4 nm magnetic core and 15 nm hydrodynamic diameters, with relatively small fraction of agglomerates. The as-prepared particles presented superparamagnetic behavior at room temperature. The in vitro hyperthermia experiments, performed in ac-field conditions under human tolerable limits, showed that the suspensions of the synthesized nanoparticles exhibit a maximum specific absorption rate (SAR) value of 11 W/g. The H-1 nuclear magnetic resonance (NMR) relaxometry measurements indicated the suspensions of NiFe2O4 have a transverse-to-longitudinal relaxivity ratio r(2)/r(1) greater than two, as required for superparamagnetic MRI contrast agents. On the basis of the parameters obtained from the magnetic measurements, by comparing the relevant theoretical models with the experimental results, we found that the presence of agglomerates, and particularly the interactions within the agglomerated nanoparticles, caused a significant increase in the hyperthermia and MRI efficiencies. On the other hand, from an applicative point of view, both the MRI contrast enhancement and the heating capabilities allow the simultaneous use of nickelferrites in diagnostic and therapeutic applications as theranostic agents. (C) 2019 Elsevier Inc. All rights reserved.
dc.description.sponsorshipUniversity of Pisa through Progetti di Ricerca di Ateneo [PRA_2017_25]en_US
dc.description.sponsorshipProf. Alessandro Lascialfari (University of Pavia, Italy) is gratefully acknowledged for organizing the SQUID and NMRD measurements and for their valuable contributions. We also thank Prof. Tezer Flrat for the preparation of the hyperthermia experiment setup, measurements, and valuable discussions. Financial support from the University of Pisa through Progetti di Ricerca di Ateneo (grant PRA_2017_25).en_US
dc.identifier.citationUmut, E., Coşkun, M., Pineider, F., Berti, D., & Güngüneş, H. (2019). Nickel ferrite nanoparticles for simultaneous use in magnetic resonance imaging and magnetic fluid hyperthermia. Journal of colloid and interface science, 550, 199-209.
dc.identifier.doi10.1016/j.jcis.2019.04.092
dc.identifier.endpage209en_US
dc.identifier.issn0021-9797
dc.identifier.issn1095-7103
dc.identifier.pmid31075674
dc.identifier.scopus2-s2.0-85065141943
dc.identifier.scopusqualityQ1
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcis.2019.04.092
dc.identifier.urihttps://hdl.handle.net/11491/6896
dc.identifier.volume550en_US
dc.identifier.wosWOS:000469902400020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüngüneş, Hakan
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofJournal Of Colloid And Interface Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSuperparamagnetismen_US
dc.subjectMagnetic Fluid Hyperthermiaen_US
dc.subjectNMR Relaxometryen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.titleNickel ferrite nanoparticles for simultaneous use in magnetic resonance imaging and magnetic fluid hyperthermia
dc.typeArticle

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