Molecularly imprinted composite bacterial cellulose nanofibers for antibiotic release

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dc.contributor.authorTamahkar Irmak, Emel
dc.contributor.authorBakhshpour, Monireh
dc.contributor.authorDenizli, Adil
dc.date.accessioned2019-05-13T08:57:59Z
dc.date.available2019-05-13T08:57:59Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractThe aim of this work is to develop drug carrier system with high loading capacity and controlled drug release profile for antibiotic release. For this purpose, composite molecularly imprinted nanofibers were prepared via in-situ graft polymerization of methacrylic acid as a monomer, N,N’-methylene bisacrylamide as a crosslinker and gentamicin sulfate as a template molecule onto surface-modified bacterial cellulose nanofibers. Gentamicin imprinted microparticles were fabricated onto bacterial cellulose nanofibers resulting in the formation of composite BC nanofibers. Thus, the composite nanofibers incorporated with gentamicin imprinted microparticles were achieved to fabricated. The in-vitro drug release tests were performed to evaluate the release performance of the resultant composite nanofibers at 37 °C. Also, kinetic models were applied to the drug release data. It was determined that the drug release from the composite molecularly imprinted nanofibers fit well in the Korsmeyer-Peppas model. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.citationTamahkar, E., Bakhshpour, M., Denizli, A. (2019). Molecularly imprinted composite bacterial cellulose nanofibers for antibiotic release. Journal of Biomaterials Science, Polymer Edition, 30(6), 450-461.
dc.identifier.doi10.1080/09205063.2019.1580665
dc.identifier.endpage461en_US
dc.identifier.issn0920-5063
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage450en_US
dc.identifier.urihttps://doi.org/10.1080/09205063.2019.1580665
dc.identifier.urihttps://hdl.handle.net/11491/1048
dc.identifier.volume30en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Inc.
dc.relation.ispartofJournal of Biomaterials Science, Polymer Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntibioticen_US
dc.subjectBacterial Celluloseen_US
dc.subjectComposite Structureen_US
dc.subjectMolecularly Imprinted Polymersen_US
dc.subjectNanofibersen_US
dc.subjectReleaseen_US
dc.titleMolecularly imprinted composite bacterial cellulose nanofibers for antibiotic release
dc.typeArticle

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