High prevalence of Hashimoto's thyroiditis in patients with polycystic ovary syndrome: Does the imbalance between estradiol and progesterone play a role?

Basit Öğe Kaydı
dc.contributor.authorArduç, Ayşe
dc.contributor.authorAyçiçek Doğan, Berçem
dc.contributor.authorBilmez, Sevgi
dc.contributor.authorİmga Nasıroğlu, Narin
dc.contributor.authorTuna, Mazhar Müslüm
dc.contributor.authorIşık, Serhat
dc.contributor.authorBerker, Dilek
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T08:57:48Z
dc.date.available2019-05-13T08:57:48Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: Some similar factors, such as genetic susceptibility and subinflammation/autoimmunity, contribute to development of both polycystic ovary syndrome (PCOS) and Hashimoto’s thyroiditis (HT), suggesting a potential pathogenic link between the two common disorders. In this study, we investigated the relationship between PCOS and HT, considering the possible effect of PCOS-related hormonal and metabolic factors on thyroid autoimmunity. Methods: Eighty-six reproductive-age women diagnosed with PCOS according to Rotterdam criteria and 60 age-BMI matched control women were included in the study. All subjects had thyroid function tests, thyroid peroxidase anti-body (anti-TPO), thyroglobulin anti-body (anti-Tg), LH, FSH, estradiol, progesterone, androgens, fasting glucose, insulin, lipid, homeostasis model assessment insulin resistance (HOMA-IR) levels, thyroid and pelvic ultrasounds. Results: TSH, anti-TPO (p?=?0.017), anti-Tg (p?=?0.014), LH, DHEAS, testosterone, and HOMA-IR levels were significantly higher and progesterone were lower in PCOS women than in controls. Free T4, free T3, FSH, estradiol levels and thyroid volume were similar between the two groups. A higher percentage of PCOS patients had elevated TSH (26.7 and 5%; p?=?0.001), anti-TPO (26.7 and 6.6%; p?=?0.002), and anti-Tg (16.2 and 5%; p?=?0.039). HT was more common in PCOS patients compared to controls (22.1 and 5%; p?=?0.004). Estradiol (p?=?0.003) were higher in anti-TPO positive PCOS women than anti-TPO negative ones. Anti-TPO was correlated positively with estradiol, estradiol/progesterone ratio, and TSH. Conclusions: This study demonstrated a higher prevalence of HT, elevated TSH, anti-TPO, and anti-Tg levels in PCOS patients. Increased estrogen and estrogen/progesterone ratio seem to be directly involved in high anti-TPO levels in PCOS patients.
dc.identifier.citationArduç, A., Ayçiçek Doğan, B., Bilmez, S., İmga Nasıroğlu, N., Tuna, M. M., Işık, S., Berker, D., Güler, S. (2015). High prevalence of Hashimoto’s thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role?. Endocrine Research, 40(4), 204-210.
dc.identifier.doi10.3109/07435800.2015.1015730
dc.identifier.endpage210en_US
dc.identifier.issn0743-5800
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.3109/07435800.2015.1015730
dc.identifier.urihttps://hdl.handle.net/11491/1012
dc.identifier.volume40en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofEndocrine Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEstradiolen_US
dc.subjectHashimoto’s Thyroiditisen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectProgesteroneen_US
dc.subjectThyroid Autoantibodiesen_US
dc.titleHigh prevalence of Hashimoto's thyroiditis in patients with polycystic ovary syndrome: Does the imbalance between estradiol and progesterone play a role?
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu