Polarographic investigation of dienogest
[ X ]
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Electrochemical Society Inc.
Erişim Hakkı
Attribution 4.0 International (CC BY 4.0)
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Dienogest (DGN), is an orally administered synthetic progestin that has shown to have selective progesterone receptor (PR) agonistic activity and oral progestational potency on endometrium. In this paper, the investigation of electrochemical reduction of Dienogest on dropping mercury electrode (DME) is achieved and resulted in a reduction scheme that involves a two electron reduction of 3-keto-delta-4-group in the A-ring of the molecule. This observation is supported by comparison of the compound with model compounds of testosterone and norethisterone. In this study, electrochemical determination of the compound and its validation is also studied by differential pulse polarograhy (DPP). The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00 × 10-6M to 1.00 × 10-4M, with LOD and LOQ values as 0.58 × 10-6M and 1.90 × 10-6M, respectively. © 2018 The Electrochemical Society.
Açıklama
Anahtar Kelimeler
[Belirlenecek]
Kaynak
Journal of the Electrochemical Society
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
165
Sayı
10
Künye
Baymak, M. S., Celik, H., Bakırhan, N. K., Uslu, B., Ozkan, S. A. (2018). Polarographic Investigation of Dienogest. Journal of The Electrochemical Society, 165(10), G128-G132.
