Polarographic investigation of dienogest

Basit Öğe Kaydı
dc.authorid0000-0002-1911-0977
dc.authorid0000-0001-5469-9142
dc.contributor.authorBaymak Çelik, Melek Şirin
dc.contributor.authorÇelik, Hayati
dc.contributor.authorKaradaş Bakırhan, Nurgül
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:38:51Z
dc.date.available2019-05-10T09:38:51Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractDienogest (DGN), is an orally administered synthetic progestin that has shown to have selective progesterone receptor (PR) agonistic activity and oral progestational potency on endometrium. In this paper, the investigation of electrochemical reduction of Dienogest on dropping mercury electrode (DME) is achieved and resulted in a reduction scheme that involves a two electron reduction of 3-keto-delta-4-group in the A-ring of the molecule. This observation is supported by comparison of the compound with model compounds of testosterone and norethisterone. In this study, electrochemical determination of the compound and its validation is also studied by differential pulse polarograhy (DPP). The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00 × 10-6M to 1.00 × 10-4M, with LOD and LOQ values as 0.58 × 10-6M and 1.90 × 10-6M, respectively. © 2018 The Electrochemical Society.
dc.identifier.citationBaymak, M. S., Celik, H., Bakırhan, N. K., Uslu, B., Ozkan, S. A. (2018). Polarographic Investigation of Dienogest. Journal of The Electrochemical Society, 165(10), G128-G132.
dc.identifier.doi10.1149/2.1211810jes
dc.identifier.endpageG132en_US
dc.identifier.issn0013-4651
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpageG128en_US
dc.identifier.urihttps://doi.org/10.1149/2.1211810jes
dc.identifier.urihttps://hdl.handle.net/11491/509
dc.identifier.volume165en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElectrochemical Society Inc.
dc.relation.ispartofJournal of the Electrochemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject[Belirlenecek]en_US
dc.titlePolarographic investigation of dienogest
dc.typeArticle

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