Effects of upper limb ischemia-reperfusion on regional oxidative stress during aortic surgery with moderate hypothermia

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dc.authoridUnal, Ertekin Utku / 0000-0002-1144-8906
dc.authoridKarduz, Gulsum / 0000-0002-0289-0401
dc.authoridBALCI, EDA / 0000-0002-8113-4080
dc.authorwosidUnal, Ertekin Utku / G-2728-2013
dc.contributor.authorBalci, Eda
dc.contributor.authorDemir, Zeliha A.
dc.contributor.authorOzay, Hulya Yigit
dc.contributor.authorVardar, Kubra
dc.contributor.authorKarduz, Gulsum
dc.contributor.authorAksu, Ugur
dc.contributor.authorOzgok, Aysegul
dc.date.accessioned2021-11-01T15:05:57Z
dc.date.available2021-11-01T15:05:57Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractIntroduction This study aims to evaluate the effect of acute, iatrogenic right arm ischemia and reperfusion (I/R) due to right axillary cannulation on regional oxidative stress using tissue perfusion markers such as central venous oxygen saturation, lactate, the difference between central venous and arterial CO2 pressure, near-infrared spectroscopy (NIRS) measurements, and biomarkers like sialic acid, malondialdehyde, advanced oxidative protein products in aortic surgery with moderate hypothermia. Methods Adult patients undergoing ascending aorta repair with antegrade cerebral perfusion via the axillary artery participated. Blood samples were collected from the internal jugular vein, right arm cubital vein, and left arm cubital vein, and analysis was performed at intraoperative time points. Results Right-arm venous oxygen saturation levels are significantly lower than left arm and central venous, as expected in iatrogenic ischemia. Right arm lactate levels are significantly higher. Somatic right arm NIRS values are significantly lower than somatic left arm. There are no significant differences for biomarkers throughout the time points. Conclusions We have concluded that well-known markers reflect the results of ischemia-reperfusion more rapidly, and are more valuable than novel biomarkers. NIRS is a promising monitor in terms of providing information about tissue oxygenation. Oxidative stress biomarkers do not change quickly enough to give useful information in a short enough period of time; moreover, their costs are high and laboratory studies take time. Although axillary cannulation is controlled limb ischemia, the local effects of I/R did not completely normalize at the end of the surgery, and this regional I/R did not affect the global body organism.
dc.identifier.doi10.1111/jocs.15409
dc.identifier.endpage1369en_US
dc.identifier.issn0886-0440
dc.identifier.issn1540-8191
dc.identifier.issue4en_US
dc.identifier.pmid33567138
dc.identifier.scopus2-s2.0-85100729456
dc.identifier.scopusqualityQ2
dc.identifier.startpage1361en_US
dc.identifier.urihttps://doi.org/10.1111/jocs.15409
dc.identifier.urihttps://hdl.handle.net/11491/7452
dc.identifier.volume36en_US
dc.identifier.wosWOS:000616673000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal Of Cardiac Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcentral venous and arterial CO2 pressure gapen_US
dc.subjectcentral venous oxygen saturationen_US
dc.subjectischemi&#8208en_US
dc.subjectreperfusion injuryen_US
dc.subjectlactateen_US
dc.subjectNIRSen_US
dc.titleEffects of upper limb ischemia-reperfusion on regional oxidative stress during aortic surgery with moderate hypothermia
dc.typeArticle

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