Design of pyrazolo-pyrrolo-pyrazines and pyrazolo-pyrrolo-diazepines via AuCl3-catalyzed and NaH-supported cyclization of N -propargyl pyrazoles

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dc.contributor.authorBaşçeken, Sinan
dc.contributor.authorBalcı, Mehmet
dc.date.accessioned2019-05-10T09:39:02Z
dc.date.available2019-05-10T09:39:02Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA concise synthetic methodology for new heterocyclic scaffolds, such as pyrazolo-pyrrolo-pyrazine and pyrazolo-pyrrolo-diazepine skeletons, was developed. The key features of this method include (i) synthesis of pyrrole-derived ?,?-alkynyl ketones, (ii) introduction of various substituents into the alkyne functionality by Sonogashira cross-coupling, (iii) synthesis of pyrazole units by the reaction of ?,?-alkynyl compounds with hydrazine monohydrate, (iv) gold-catalyzed cyclization of pyrazoles with alkyne units, and (v) cyclization with NaH. Furthermore, this methodology allows various substituents to be introduced into all positions of the target compounds. © 2015 American Chemical Society.
dc.identifier.citationBasceken, S., & Balci, M. (2015). Design of pyrazolo-pyrrolo-pyrazines and pyrazolo-pyrrolo-diazepines via AuCl3-catalyzed and NaH-supported cyclization of N-propargyl pyrazoles. The Journal of organic chemistry, 80(8), 3806-3814.
dc.identifier.doi10.1021/acs.joc.5b00034
dc.identifier.endpage3814en_US
dc.identifier.issn0022-3263
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage3806en_US
dc.identifier.urihttps://doi.org/10.1021/acs.joc.5b00034
dc.identifier.urihttps://hdl.handle.net/11491/588
dc.identifier.volume80en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofJournal of Organic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleDesign of pyrazolo-pyrrolo-pyrazines and pyrazolo-pyrrolo-diazepines via AuCl3-catalyzed and NaH-supported cyclization of N -propargyl pyrazoles
dc.typeArticle

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