The effect of Lucilia sericata larval excretion/secretion (ES) products on cellular responses in wound healing

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dc.authoridTaylan Ozkan, Aysegul / 0000-0001-8421-3625
dc.authorwosidTaylan Ozkan, Aysegul / B-9721-2016
dc.contributor.authorGazi, U.
dc.contributor.authorTaylan-Ozkan, A.
dc.contributor.authorMumcuoglu, K. Y.
dc.date.accessioned2021-11-01T15:05:48Z
dc.date.available2021-11-01T15:05:48Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractChronic wounds are still regarded as a serious public health concern, which are on the increase mainly due to the changes in life styles and aging of the human population. There are different types of chronic wounds, each of which requires slightly different treatment strategies. Nevertheless, wound bed preparation is included in treatment of all types of chronic wounds and involves tissue debridement, inflammation, and infection control, as well as moisture balance and epithelial edge advancement. Maggot therapy (MT) is a form of biological debridement which involves the application of live medical grade Lucilia sericata (Meigen, 1826) (Diptera: Calliphoridae) larvae. Whereas it was initially thought to act mainly through debridement, today MT is known to influence all four overlapping physiological phases of wound repair: homeostasis, inflammation, proliferation, and remodelling/maturing. During MT, medical-grade larvae are applied either freely or enclosed in tea-bag like devices (biobag) inside the wounds, which suggests that larva excretion/secretion (ES) products can facilitate the healing processes directly without the need of direct contact with the larvae. This review summarizes the relevant literature on ES-mediated effects on the cellular responses involved in wound healing.
dc.identifier.doi10.1111/mve.12497
dc.identifier.endpage266en_US
dc.identifier.issn0269-283X
dc.identifier.issn1365-2915
dc.identifier.issue3en_US
dc.identifier.pmid33314340
dc.identifier.scopus2-s2.0-85097490849
dc.identifier.scopusqualityQ1
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.1111/mve.12497
dc.identifier.urihttps://hdl.handle.net/11491/7405
dc.identifier.volume35en_US
dc.identifier.wosWOS:000598348100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMedical And Veterinary Entomology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic wounden_US
dc.subjectexcretionen_US
dc.subjecthealingen_US
dc.subjectLucilia cuprinaen_US
dc.subjectLucilia sericataen_US
dc.subjectmaggot therapyen_US
dc.subjectsecretionen_US
dc.titleThe effect of Lucilia sericata larval excretion/secretion (ES) products on cellular responses in wound healing
dc.typeReview Article

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