Comparison of the effects of Neostigmine and Sugammadex on Colonic Anastomotic Strength in Rats

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dc.contributor.authorDoğan, Gül
dc.contributor.authorDoğan, Güvenç
dc.contributor.authorKayır, Selçuk
dc.contributor.authorYağan, Özgür
dc.contributor.authorHancı, Volkan
dc.date.accessioned2020-01-30T06:54:27Z
dc.date.available2020-01-30T06:54:27Z
dc.date.issued2020en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground:After colorectal surgery, anastomotic leakage is a major cause of mortality andmorbidity. There are many factors affecting anastomotic leakage. It is known that agentssuch as neostigmine that is used to reverse neuromuscular blockade have certain effectson anastomosis. In our study, in which we planned to test this hypothesis, we aimed tocompare the possible effects of different doses of sugammadex and neostigmine on colonanastomosis strength in a colonic resection anastomosis model in rats.Materials and methods:Forty adult Wistar albino male rats were divided into five groups ascontrol (group C), Sugammadex 16 mg/kg (group SL), sugammadex 96 mg/kg (group SH),neostigmine 0.3mmol/kg (group NL), and neostigmine 1.5mmol/kg (group NH). The trans-verse colons of all rats were resected, and colonic anastomosis was performed. Appropriatedrug doses according to the groups were given on the postoperative seventh day, and tissuehydroxyproline (TH) level and anastomotic bursting pressure were measured.Results:Anastomotic bursting pressure values were statistically significantly different be-tween the groups (P¼0.001). The bursting pressure in group SH was significantly highercompared with group C, group NL, and group NH. The hydroxyproline values were sta-tistically significantly different between the groups (P¼0.015). According to the post hoctest results, the difference was between group SH and group C (P¼0.007). There were nosignificant differences between the other groups (P>0.05). There was no significant dif-ference in terms of intra-abdominal adhesion rates between the groups.Conclusions:In our study, we found that low and high doses of neostigmine had no variableeffect on anastomosis, but high dose of sugammadex (96 mg/kg) had an increasing effecton intestinal anastomosis strength
dc.description.provenanceSubmitted by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-01-30T06:54:11Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut Arslan (umutarslan@hitit.edu.tr) on 2020-01-30T06:54:27Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-01-30T06:54:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.citationDogan, G., Dogan, G., Kayir, S., Yagan, O., & Hanci, V. (2020). Comparison of the Effects of Neostigmine and Sugammadex on Colonic Anastomotic Strength in Rats. Journal of Surgical Research, 248, 123-128.
dc.identifier.doi10.1016/j.jss.2019.12.006
dc.identifier.endpage128en_US
dc.identifier.issn0022-4804
dc.identifier.scopusqualityQ1
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2019.12.006
dc.identifier.urihttps://hdl.handle.net/11491/5664
dc.identifier.volume248en_US
dc.identifier.wosWOS:000517747200016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofJournal of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSugammadexen_US
dc.subjectBursting Pressureen_US
dc.subjectNeostigmineen_US
dc.subjectHydroxyprolineen_US
dc.titleComparison of the effects of Neostigmine and Sugammadex on Colonic Anastomotic Strength in Rats
dc.typeArticle

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