Determination of dissociation constants of folinic acid (leucovorin), 5-fluorouracil, and irinotecan in hydro-organic media by a spectrophotometry method
[ X ]
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, a multiwavelength spectrophotometry method was used for the determination of the dissociation constants of drugs used for treatment of colorectal cancer, folinic acid (leucovorin), 5-fluorouracil, and irinotecan, in water and acetonitrile-water binary mixtures up to a 0.50 volume fraction at 25 °C and an ionic strength of 0.1 mol•L-1 KCl. The absorbance/pH profiles were assessed and found to conform to those of polyprotic acids. Data evaluation was performed using the STAR software program which calculates stability constants and molar absorbances of the pure species by multilinear regression. A linear relationship between acidity constants and the mole fraction of acetonitrile in the solvent mixture was observed. The effect of solvent properties on acid-base behavior is discussed. © 2010 American Chemical Society.
Açıklama
Anahtar Kelimeler
[Belirlenecek]
Kaynak
Journal of Chemical and Engineering Data
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
55
Sayı
8
Künye
S?anli, N., S?anli, S., & Alsancak, G. (2010). Determination of dissociation constants of folinic acid (leucovorin), 5-fluorouracil, and irinotecan in hydro-organic media by a spectrophotometric method. Journal of Chemical & Engineering Data, 55(8), 2695-2699.
