Determination of dissociation constants of folinic acid (leucovorin), 5-fluorouracil, and irinotecan in hydro-organic media by a spectrophotometry method

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dc.contributor.authorŞanlı, Nurullah
dc.contributor.authorŞanlı, Senem
dc.contributor.authorAlsancak, Güleren
dc.date.accessioned2019-05-10T09:38:56Z
dc.date.available2019-05-10T09:38:56Z
dc.date.issued2010
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this study, a multiwavelength spectrophotometry method was used for the determination of the dissociation constants of drugs used for treatment of colorectal cancer, folinic acid (leucovorin), 5-fluorouracil, and irinotecan, in water and acetonitrile-water binary mixtures up to a 0.50 volume fraction at 25 °C and an ionic strength of 0.1 mol•L-1 KCl. The absorbance/pH profiles were assessed and found to conform to those of polyprotic acids. Data evaluation was performed using the STAR software program which calculates stability constants and molar absorbances of the pure species by multilinear regression. A linear relationship between acidity constants and the mole fraction of acetonitrile in the solvent mixture was observed. The effect of solvent properties on acid-base behavior is discussed. © 2010 American Chemical Society.
dc.identifier.citationS?anli, N., S?anli, S., & Alsancak, G. (2010). Determination of dissociation constants of folinic acid (leucovorin), 5-fluorouracil, and irinotecan in hydro-organic media by a spectrophotometric method. Journal of Chemical & Engineering Data, 55(8), 2695-2699.
dc.identifier.doi10.1021/je100072n
dc.identifier.endpage2699en_US
dc.identifier.issn0021-9568
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage2695en_US
dc.identifier.urihttps://doi.org/10.1021/je100072n
dc.identifier.urihttps://hdl.handle.net/11491/552
dc.identifier.volume55en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Chemical and Engineering Data
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleDetermination of dissociation constants of folinic acid (leucovorin), 5-fluorouracil, and irinotecan in hydro-organic media by a spectrophotometry method
dc.typeArticle

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