Boric acid-impregnated silk fibroin/gelatin/hyaluronic acid-based films for improving the wound healing process

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dc.contributor.authorÖzen, Nurten
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorEmik, Serkan
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-11-01T15:06:07Z
dc.date.available2021-11-01T15:06:07Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.description.abstractRecently, with the progression in wound dressings, the importance of the biocompatible material with enhanced features for potential applications in the biomedical field has been more developed. Current strategies focus on the acceleration of the wound healing by systematically designed dressing materials. In this study, biocompatible hydrogel films with the combination of silk fibroin, hyaluronic acid and gelatin biopolymers were fabricated. To gain the enhanced wound healing behavior of wound dressings, boric acid (BA) was formulated in various ratios. The prepared hydrogel films were characterized in terms of FTIR, TGA, DSC, and SEM analysis. Following to the swelling and mechanical tests, in vitro biocompatibility and wound healing tests were performed against L929 fibroblast cell line. Results suggest that the presence of 1% (wt/vol) BA in the formulation of silk fibroin/gelatin/hyaluronic acid based hydrogel films is the key in providing such an enhanced mechanical and wound healing feature and may offer an alternative approach for wound healing treatment.
dc.description.sponsorshipDemiroglu Bilim UniversityDemiroglu Bilim University [2019/01]en_US
dc.description.sponsorshipDemiroglu Bilim University, Grant/Award Number: 2019/01en_US
dc.identifier.citationÖzen, N., Özbaş, Z., Izbudak, B., Emik, S., Özkahraman, B., & Bal?Öztürk, A. (2021). Boric acid?impregnated silk fibroin/gelatin/hyaluronic acid?based films for improving the wound healing process. Journal of Applied Polymer Science, 51715.
dc.identifier.doi10.1002/app.51715
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.scopus2-s2.0-85116110558
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.51715
dc.identifier.urihttps://hdl.handle.net/11491/7496
dc.identifier.wosWOS:000702878900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzkahraman, Bengi
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal Of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomaterialsen_US
dc.subjectDifferential Scanning Calorimetryen_US
dc.subjectFilmsen_US
dc.subjectMechanical Propertiesen_US
dc.subjectThermogravimetric Analysisen_US
dc.titleBoric acid-impregnated silk fibroin/gelatin/hyaluronic acid-based films for improving the wound healing process
dc.typeArticle

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