Renal medullary carcinoma; A rare entity

Basit Öğe Kaydı
dc.contributor.authorÇalışkan, Selahattin
dc.contributor.authorGökçe, Ali Murat
dc.contributor.authorGümrükçü, Gülistan
dc.contributor.authorÖnenerk, Mine
dc.date.accessioned2019-05-10T09:39:47Z
dc.date.available2019-05-10T09:39:47Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractRenal medullary carcinoma (RMC) is an uncommon aggressive neoplasm of the kidney. RMC is biologically aggressive with a very poor prognosis, and metastasis is seen in up to 95% of the patients at diagnosis or shortly thereafter. The common sites of metastasis are respectively lymph nodes, lungs, livers, and adrenal glands in order of frequency. The presence of poorly differentiated eosinophilic cells in a characteristic fibro-inflammatory stroma is seen in histological examination. The origin and pathogenesis of RMC are unclear. The radiographical and pathological findings suggest that RMC probably originates in the calyceal epithelium in or near the renal papillae, which could be the result of chronic ischemic damage in the renal papillae epithelium by sickled erythrocytes. Positivity of VEGF and HIF-1? supports the chronic hypoxia that may be caused in the pathogenesis of RMC. Other factors such as genetic or environmental factors are important. Although hemoglobinopathy is very common, RMC is very rare. An understanding of the molecular and genetic factors of this rare disease is important for its prevention and treatment. We herein describe an adult Turkish patient, who presented with hematuria. The diagnosis was RMC after pathological examination. © 2017, Shiraz University of Medical Sciences. All rights reserved.
dc.identifier.citationÇalışkan, S., Gökçe, A. M., Gümrükçü, G., & Önenerk, M. (2017). Renal medullary carcinoma; A rare entity. Iranian journal of medical sciences, 42(2), 215.
dc.identifier.endpage218en_US
dc.identifier.issn0253-0716
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage215en_US
dc.identifier.urihttps://hdl.handle.net/11491/775
dc.identifier.volume42en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherShiraz University of Medical Sciences
dc.relation.ispartofIranian Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCase Reportsen_US
dc.subjectKidney Neoplasmsen_US
dc.subjectMedullary Carcinomaen_US
dc.titleRenal medullary carcinoma; A rare entity
dc.typeArticle

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