Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk

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dc.authorid0000-0001-7639-1122
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorÇetinay Aydın, Pınar
dc.contributor.authorUysal, Mehmet Atilla
dc.contributor.authorŞentürk Çiftçi, Hayriye
dc.contributor.authorSever, Ülgen
dc.contributor.authorYavuz, Fatih Kasım
dc.contributor.authorAydın, Nazan
dc.contributor.authorNursal, Ayşe Feyda
dc.date.accessioned2019-05-10T09:39:25Z
dc.date.available2019-05-10T09:39:25Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine dependence (ND) and Sch+ND risk in Turkish population and to evaluate by bioinformatic analysis. Methods Present study included 161 individuals with ND, 223 patients with Sch+ND, and 96 non-smoker controls. MAOB A644G variant was analyzed using PCR-RFLP method. As the MAOB gene is located on the X chromosome, each gender was analysed separately. Results The total distributions of AA, AG and GG genotypes of MAOB gene A644G were 44.7%, 22.4% and 32.9% in the ND group, 45.3%, 25.1% and 29.6% in the Sch+ND group and, 44.8, 22.9% and 32.3% in non-smoker controls. No significant differences were observed between groups for the MAOB A644G genotype and allele frequencies when female group compared to male group (p > 0.05). Examination of disease associations of SNPs from each miRNA gene region in GWAS databases yielded results for aging, bipolar disorder, autoimmune, and neurological diseases. Discussion Our results indicate that the MAOB gene A644G variant is not associated with ND and/or Sch susceptibility in the Turkish population. © 2019, Universidade de Sao Paulo. All rights reserved.
dc.identifier.citationPehlivan, S., Aydin, P. C., Uysal, M. A., Ciftci, H. S., Sever, U., YAVUZ, F. K., ... & Nursal, A. F. (2019). Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk. Archives of Clinical Psychiatry (São Paulo), 46(1), 21-24.
dc.identifier.doi10.1590/0101-60830000000186
dc.identifier.endpage24en_US
dc.identifier.issn0101-6083
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1590/0101-60830000000186
dc.identifier.urihttps://hdl.handle.net/11491/689
dc.identifier.volume46en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversidade de Sao Paulo
dc.relation.ispartofRevista de Psiquiatria Clinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en*
dc.subjectMonoamine Oxidase Ben_US
dc.subjectNicotine Dependenceen_US
dc.subjectSchizophreniaen_US
dc.subjectVarianten_US
dc.titleEffect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk
dc.typeArticle

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