Can altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?

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dc.authoridEryavuz Onmaz, Duygu / 0000-0001-8564-1824
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorOnmaz, Duygu Eryavuz
dc.contributor.authorAltunhan, Huseyin
dc.contributor.authorIlhan, Merve
dc.date.accessioned2021-11-01T15:05:50Z
dc.date.available2021-11-01T15:05:50Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractProblem The cesarean section (CS) rate has increased significantly in North America, Western Europe, and Latin America. However, it has been reported that the incidence of inflammatory and autoimmune diseases such as asthma and type 1 diabetes increased in parallel with CS in these countries. Our aim was to investigate the expression level of miRNAs associated with inflammatory response and autoimmune diseases in colostrum samples and contribute to elucidating the role of CS in the pathogenesis of immune system-related diseases. Method of study Colostrum samples were taken from voluntary mothers who had 40 normal and 50 cesarean births. miRNAs were extracted from colostrums and detected to miRNA expression profiling (eighty-four miRNAs) by quantitative real-time PCR with the Fluidigm integrated microfluidic circuit technology. Results There was a statistically significant change in the expression levels of 17 miRNAs in the colostrums of mothers who had normal and cesarean delivery (p < .05), and all of miRNAs were upregulated in the colostrums of mothers who have had cesarean delivery. Conclusion Our best knowledge is that the study we conducted was the first to investigate the effect of delivery method (CS or normal) on the miRNA profile of colostrum. Cesarean delivery is a potential risk factor for inflammatory and immune system-related diseases in children due to dysregulation in miRNA expression.
dc.description.sponsorshipNecmettin Erbakan UniversitesiNecmettin Erbakan University [181218016]en_US
dc.description.sponsorshipNecmettin Erbakan Universitesi, Grant/ Award Number: 181218016en_US
dc.identifier.doi10.1111/aji.13472
dc.identifier.issn1046-7408
dc.identifier.issn1600-0897
dc.identifier.issue4en_US
dc.identifier.pmid34080731
dc.identifier.scopus2-s2.0-85107033097
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/aji.13472
dc.identifier.urihttps://hdl.handle.net/11491/7418
dc.identifier.volume86en_US
dc.identifier.wosWOS:000657361000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAmerican Journal Of Reproductive Immunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCesarean sectionen_US
dc.subjectnormal birthen_US
dc.subjectmiRNAen_US
dc.subjectautoimmune diseaseen_US
dc.subjectinflammationen_US
dc.titleCan altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?
dc.typeArticle

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