Characterization and antibacterial activity of gelatin-gellan gum bilayer wound dressing

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dc.authoridPerçin, Işık / 0000-0002-9453-4462
dc.authoridKılıç Süloğlu, Aysun / 0000-0003-0914-1128
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorBayrak, Gülşen
dc.contributor.authorTamahkar, Emel
dc.contributor.authorPerçin, Işık
dc.contributor.authorKılıç Süloğlu, Aysun
dc.contributor.authorBor, Filiz
dc.date.accessioned2021-11-01T15:05:59Z
dc.date.available2021-11-01T15:05:59Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Polimer Malzeme Mühendisliği Bölümü
dc.description.abstractBilayer wound dressing systems consisting of various biopolymers have been preferred in biomedical applications due to its enhanced advantages in comparison with conventional systems. The aim of this research was to develop a novel bilayer wound dressing based on gelatin (G) and gellan gum (GG). The bilayer was composed of an upper layer impregnated with antibiotic drug sodium ampicillin and a drug-free lower sponge layer. The bilayer hydrogels were characterized by FTIR, TGA, DSC and SEM analyses including swelling behaviors and hydrolytic degradation tests. To achieve faster healing of the wound by prevention of the bacterial infection, the bilayer hydrogels were developed as antibiotic-releasing vehicles. Herein, release study of sodium ampicillin was performed in PBS to simulate the physiological micro-environment. Additionally, cyto-compatibility tests of L929 fibroblast cells showed the high proliferation and survival through drug-loaded GG and G hydrogels (GG-G-D) after 24h, 48h and 72h incubation. This novel GG-G bilayer hydrogel could be a good candidate as wound dressing.
dc.description.sponsorshipScientific Projects Coordination Unit of Hitit UniversityHitit University [MUH19001.19.004]en_US
dc.description.sponsorshipThe financial support from the Scientific Projects Coordination Unit of Hitit University under the project number MUH19001.19.004 is gratefully acknowledged.en_US
dc.identifier.citationÖzkahraman, B., Özbaş, Z., Bayrak, G., Tamahkar, E., Perçin, I., Kılıç Süloğlu, A., & Boran, F. (2021). Characterization and antibacterial activity of gelatin–gellan gum bilayer wound dressing. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-12.
dc.identifier.doi10.1080/00914037.2021.1960341
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.scopus2-s2.0-85112551430
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/00914037.2021.1960341
dc.identifier.urihttps://hdl.handle.net/11491/7459
dc.identifier.wosWOS:000685014000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzkahraman, Bengi
dc.institutionauthorTamahkar, Emel
dc.language.isoen
dc.publisherTaylor & Francis As
dc.relation.ispartofInternational Journal Of Polymeric Materials And Polymeric Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntibacterialen_US
dc.subjectBilayer Wound Dressing Materialsen_US
dc.subjectControlled Drug Deliveryen_US
dc.subjectMTT Assayen_US
dc.titleCharacterization and antibacterial activity of gelatin-gellan gum bilayer wound dressing
dc.typeArticle

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