A sensitive and selective RP-LC method for the simultaneous determination of the antihypertensive drugs, enalapril, lercanidipine, nitrendipine and their validation

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dc.authorid0000-0002-7079-7604
dc.authorid0000-0003-2793-7154
dc.authorid0000-0001-7494-3077
dc.contributor.authorKurbanoğlu, Sevinç
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:38:50Z
dc.date.available2019-05-10T09:38:50Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA RP-LC method is presented, which is sensitive and selective for the simultaneous determination of enalapril-lercanidipine and enalapril-nitrendipine binary mixtures in their pharmaceutical dosage forms. The analyte peaks were detected using the LC method with the mobile phase ratio of methanol: water (70:30 v/v, pH 3.0) and a 1.0 mL min-1 flow rate. The detection wavelength was selected at 210 nm using photo diode array detector and column temperature was optimized to 30 C. Linearity was obtained at different concentration ranges for all working pharmaceutically active compounds between 0.5 and 25 ?g mL-1. The proposed methods were extensively validated according to USP 27 requirements and ICH guidelines. The methods were applied to the analysis of pharmaceutical dosage forms containing binary mixtures of enalapril-lercanidipine and enalapril-nitrendipine. Moreover, the proposed methods were applied for the degradation studies of the selected compounds. Degradation studies were conducted using stress conditions such as UV light, acidic and alkaline hydrolysis, oxidation and heat in oven, to evaluate the ability of the separation of the response of standard compounds from their degradation products. © 2013 Springer-Verlag Berlin Heidelberg.
dc.identifier.citationKurbanoglu, S., Gumustas, M., Uslu, B., Ozkan, S.A. (2013). A Sensitive and Selective RP-LC Method for the Simultaneous Determination of the Antihypertensive Drugs, Enalapril, Lercanidipine, Nitrendipine and Their Validation. Chromatographia, 76(21-22), 1477-1485.
dc.identifier.doi10.1007/s10337-013-2465-z
dc.identifier.endpage1485en_US
dc.identifier.issn0009-5893
dc.identifier.issue21-22en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1477en_US
dc.identifier.urihttps://doi.org/10.1007/s10337-013-2465-z
dc.identifier.urihttps://hdl.handle.net/11491/497
dc.identifier.volume76en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofChromatographia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEnalaprilen_US
dc.subjectLercanidipineen_US
dc.subjectNitrendipineen_US
dc.subjectReversed-Phase Liquid Chromatographyen_US
dc.titleA sensitive and selective RP-LC method for the simultaneous determination of the antihypertensive drugs, enalapril, lercanidipine, nitrendipine and their validation
dc.typeArticle

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