Development and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present paper, sensitive, rapid, and different analytical methodology was developed for the determination of anticancer drug epirubicin (EPR). The mixture of epirubicin and moxifloxacin as internal standard was separated on a reversed phase Waters Spherisorb ODS1 column (250mm × 4.6mm × 5mm) using acetonitrile/water (30:70 v/v) mixture containing 15 mM phosphoric acid as mobile phase at 0.6 mL min-1 flow rate and 30 C. Also degradation studies were conducted as stress conditions of UV light, acidic hydrolysis, alkaline hydrolysis, oxidation, and heat in oven (100°C), to evaluate the ability of the proposed method for the separation of EPR from its degradation products. The validated method suggests routine analysis of EPR in differently equipped laboratories. © 2014 Copyright Taylor & Francis Group, LLC.
Açıklama
Anahtar Kelimeler
Epirubicin, Liquid Chromatography, Stability-Indicating High-Performance, Validation
Kaynak
Journal of Liquid Chromatography and Related Technologies
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
37
Sayı
11
Künye
Kurbanoglu, S., Palabiyik, B. B., Gumustas, M., Şanlı, S., Uslu, B., & Ozkan, S. A. (2014). Development and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals. Journal of Liquid Chromatography & Related Technologies, 37(11), 1583-1596.
