Development and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals

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dc.authorid0000-0002-7079-7604
dc.authorid0000-0003-2793-7154
dc.authorid0000-0001-7494-3077
dc.contributor.authorKurbanoğlu, Sevinç
dc.contributor.authorBozal Palabıyık, Burçin
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorŞanlı, Senem
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-13T09:02:28Z
dc.date.available2019-05-13T09:02:28Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn the present paper, sensitive, rapid, and different analytical methodology was developed for the determination of anticancer drug epirubicin (EPR). The mixture of epirubicin and moxifloxacin as internal standard was separated on a reversed phase Waters Spherisorb ODS1 column (250mm × 4.6mm × 5mm) using acetonitrile/water (30:70 v/v) mixture containing 15 mM phosphoric acid as mobile phase at 0.6 mL min-1 flow rate and 30 C. Also degradation studies were conducted as stress conditions of UV light, acidic hydrolysis, alkaline hydrolysis, oxidation, and heat in oven (100°C), to evaluate the ability of the proposed method for the separation of EPR from its degradation products. The validated method suggests routine analysis of EPR in differently equipped laboratories. © 2014 Copyright Taylor & Francis Group, LLC.
dc.identifier.citationKurbanoglu, S., Palabiyik, B. B., Gumustas, M., Şanlı, S., Uslu, B., & Ozkan, S. A. (2014). Development and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals. Journal of Liquid Chromatography & Related Technologies, 37(11), 1583-1596.
dc.identifier.doi10.1080/10826076.2013.803202
dc.identifier.endpage1596en_US
dc.identifier.issn1082-6076
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1583en_US
dc.identifier.urihttps://doi.org/10.1080/10826076.2013.803202
dc.identifier.urihttps://hdl.handle.net/11491/1260
dc.identifier.volume37en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Inc.
dc.relation.ispartofJournal of Liquid Chromatography and Related Technologies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpirubicinen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectStability-Indicating High-Performanceen_US
dc.subjectValidationen_US
dc.titleDevelopment and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals
dc.typeArticle

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