Evaluation of relationship between inflammatory markers and hyperemesis gravidarumin patients admitted to emergency department

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dc.authoridEmektar, Emine / 0000-0002-6056-4401
dc.contributor.authorKan, Eda
dc.contributor.authorEmektar, Emine
dc.contributor.authorCorbacioglu, Kerem
dc.contributor.authorSafak, Tuba
dc.contributor.authorSariaydin, Tuba
dc.contributor.authorCevik, Yunsur
dc.date.accessioned2021-11-01T15:05:02Z
dc.date.available2021-11-01T15:05:02Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description11th European Congress on Emergency Medicine -- 2017 -- Athens, GREECE
dc.description.abstractBackground: Hyperemesis gravidarum (HG) is defined as severe nausea and vomiting in pregnancy and considered as one of the most frequent causes to emergency department (ED) admissions. Previous research has shown that HG is associated with systemic inflammation, but there have been no prospective studies to explore this link. The objective of this study was to assess the impact of inflammation in HG pathophysiology and to investigate the association between severity of HG and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and CRP in patients who were admitted to ED with nausea and vomiting. Methods: This prospective study has been conducted in a tertiary clinic between 2015 and 2016. A total of 162 patients with b16 weeks gestation with singleton pregnancies and without any chronic diseases enrolled in the study. The study group consisted of 113 patients with HG and the control group included 49 healthy subjects. PUQE Index and VAS were used to evaluate the severity of symptoms. Results: Demographical data were similar between both groups. The study group demonstrated significantly higher NLR, PLR and CRP levels (NLR 3.39 vs 2.5, p = 0.001; PLR 134.3 vs 111.2, p = 0.005; CRP 0.85 mg/dL vs 0.19 mg/dL, p = 0.001). While NLR and PLR levels were not correlated with severity of HG, CRP levels were associated with severity of disease (p=0.001) regarding to PUQE index. Conclusion: NLR and PLR are easily obtained and routinely used diagnostic tools for various inflammatory diseases. Measurement of this markers might provide useful information in HG pathogenesis and diagnosis. (C) 2019 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.ajem.2019.05.007
dc.identifier.endpage295en_US
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.issue2en_US
dc.identifier.pmid31118136
dc.identifier.scopus2-s2.0-85065772497
dc.identifier.scopusqualityQ1
dc.identifier.startpage292en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2019.05.007
dc.identifier.urihttps://hdl.handle.net/11491/7061
dc.identifier.volume38en_US
dc.identifier.wosWOS:000535813900024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.ispartofAmerican Journal Of Emergency Medicine
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHyperemesis gravidarumen_US
dc.subjectInflammationen_US
dc.subjectNLRen_US
dc.subjectPLRen_US
dc.subjectEmergencyen_US
dc.titleEvaluation of relationship between inflammatory markers and hyperemesis gravidarumin patients admitted to emergency department
dc.typeConference Object

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