The negative effect of desflurane on reproductive capacity in female rats

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dc.contributor.authorIurkler, C.
dc.contributor.authorIKulhan, M.
dc.contributor.authorKulhan, N. G.
dc.contributor.authorOnat, T.
dc.contributor.authorYildirim, E.
dc.contributor.authorKaplan, S.
dc.contributor.authorDine, K.
dc.date.accessioned2021-11-01T15:05:11Z
dc.date.available2021-11-01T15:05:11Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractAIM: The aim of this study was to determine the effect of desflurane on reproductive capacity in female rats through a study of biochemical evaluations. METHOD: After experimental procedure, the blood samples of female rats were collected, and the malondialdehyde, interleukin-1-beta, total glutathione and superoxide dismutase levels were measured to evaluate oxidative stress. In addition to biochemical evaluations, the reproductive performance of the experimental groups was also examined. RESULTS: The results of our study demonstrated that in blood samples of desflurane-treated groups of rats, the parameters indicating oxidative stress and inflammation increased, and antioxidant parameters decreased (p < 0.05). It was also proven that repeated desflurane doses caused infertility in female rats, prolonged the gestation period and reduced the number of offspring. CONCLUSIONS: This study showed that recurrent desflurane application can cause infertility problems through oxidative stress in female rats (Tab. 3, Fig. 1, Ref. 25).
dc.identifier.doi10.4149/BLL2020_009
dc.identifier.endpage66en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue1en_US
dc.identifier.pmid31950841
dc.identifier.scopus2-s2.0-85077941976
dc.identifier.scopusqualityQ2
dc.identifier.startpage62en_US
dc.identifier.urihttps://doi.org/10.4149/BLL2020_009
dc.identifier.urihttps://hdl.handle.net/11491/7158
dc.identifier.volume121en_US
dc.identifier.wosWOS:000507926100009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdesfluraneen_US
dc.subjectinfertilityen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.subjectreproductive capacityen_US
dc.titleThe negative effect of desflurane on reproductive capacity in female rats
dc.typeArticle

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