The Effect of Folic Acid- and Caffeic Acid-Functionalized SPION on Different Cancer Cell Lines

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dc.authorid0000-0003-3668-6975
dc.contributor.authorDönmez Güngüneş, Çiğdem
dc.contributor.authorAlpsoy, Lokman
dc.contributor.authorBaykal, Abdulhadi
dc.contributor.authorNawaz, Muhammad
dc.contributor.authorÜlker Akal, Zeynep
dc.date.accessioned2019-05-13T09:04:41Z
dc.date.available2019-05-13T09:04:41Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractIn this study, caffeic acid (CFA)- and folic acid (FA)-conjugated superparamagnetic iron oxide bio-nanocomposite (SPION@PEG-FA-@CFA) was prepared and its cytotoxic and apoptotic effects against murine fibroblast (L929), glioblastoma (U87), adenocarcinoma, human breast cancer (MCF-7), epithelioid cervix carcinoma (HeLa), and lung carcinoma (A549) have been determined. A real-time cell analyzer system (RTCA) for cytotoxicity, annexin assay and TUNEL, caspase 3/7 expression level, and caspase 3/7 activities for apoptosis were used. The RTCA showed that the cytotoxic effects of the bio-nanocomposite were higher in U87, MCF-7, and HeLa cells (which are folic acid-positive cells (FAR (+))). TUNEL, annexin, and caspase assay results indicated that the bio-nanocomposite caused apoptotic and necrotic impacts on cells. Necrotic and apoptotic cell ratios in FAR-positive cells (L929 and A549) were lesser than those in U87, MCF-7, and HeLa cells (FAR (+)). Therefore, the obtained results showed that the bio-nanocomposite can be used as a nano-medicine for biomedical application (cancer treatments). Moreover, this work can also be useful for designing other functionalized materials which could act as biomaterial. This study will be also informative for the researchers to design novel materials for biomedical applications. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.citationGungunes, C. D., Alpsoy, L., Baykal, A., Nawaz, M., & Akal, Z. Ü. (2018). The effect of folic acid-and caffeic acid-functionalized SPION on different cancer cell lines. Journal of Superconductivity and Novel Magnetism, 31(11), 3579-3588.
dc.identifier.doi10.1007/s10948-018-4618-7
dc.identifier.endpage3588en_US
dc.identifier.issn1557-1939
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage3579en_US
dc.identifier.urihttps://doi.org/10.1007/s10948-018-4618-7
dc.identifier.urihttps://hdl.handle.net/11491/1626
dc.identifier.volume31en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer New York LLC
dc.relation.ispartofJournal of Superconductivity and Novel Magnetism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCaffeic Aciden_US
dc.subjectCancer Treatmenten_US
dc.subjectFolic Aciden_US
dc.subjectSPION Bio-nanocompositeen_US
dc.titleThe Effect of Folic Acid- and Caffeic Acid-Functionalized SPION on Different Cancer Cell Lines
dc.typeArticle

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